Materials for phototherapies of ophthalmic diseases
AssigneeEyebright Medical Technology (Beijing) Co., Ltd.
InventorsXince Sui, Yongji Wei, Jiangbing Xie
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Abstract
The present invention relates to a medicinal material for light therapy, comprising a matrix material and a photosensitizer, wherein the photosensitizer is dispersed inside the matrix material by copolymerization, is mixed inside the matrix material, or attached to the surface of the matrix material by surface grafting, modification, coating and the like. The present material can kill diseased tissue cells with a radiation under selected wavelength so as to obtain a phototherapy treatment of ophthalmic diseases. The present invention also provides a process for preparing the material and a use in preparing an ophthalmic medical device.
Claims7
An ophthalmic implant comprising an ophthalmic material for a light therapy of an ocular disease, comprising:
- a matrix material, in which the matrix material is a copolymer obtained by at least one monomer selected from the group consisting of methyl methacrylate, ethyl methacrylate, ethyl acrylate, butyl methacrylate, butyl acrylate, hydroxyethyl methacrylate, and hydroxyethyl acrylate and at least one monomer selected from the group consisting of ethylene glycol dimethacrylate, butanediol dimethacrylate and hexanediol dimethacrylate;
- and
- at least one photosensitizer selected from the group consisting of porphyrins, metalloporphyrins, porphins, chlorophyll or derivatives thereof,
- wherein the at least one photosensitizer is fixed inside the matrix material, and the photosensitizer is polymerized with the matrix material,
- wherein the amount of the at least one photosensitizer is less than 0.1 wt % relative to the total weight of the matrix material,
- wherein the at least one photosensitizer is a photothermal-type photosensitizer capable of generating heat such that, when subjected to a laser light source having a wavelength between 600 nm and 900 nm, the ophthalmic material experiences a temperature increase of about 6° C. to about 12° C., and
- wherein the ophthalmic material excludes a UV absorber.
Dependencies are inferred from the claim text.