Process and compositions for enhancing energy expenditure
OwnerMuhammed Majeed, Kalyanam Nagabhushanam +2inventors
InventorsMuhammed Majeed, Kalyanam Nagabhushanam, Lakshmi Mundkur, Mohammad Mansoor Ansari
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Abstract
The invention discloses a composition comprising Cyperus rotundus extract and Passiflora edulis extract comprising piceatannol, scirpusin B, scirpusin A, cyperusphenol A and cyperusphenol B, standardized to contain 6-10% w/w total stilbenes. The invention also discloses the use of the above mentioned composition in enhancing energy expenditure in mammalian adipose cellular systems by the conversion of white adipose tissues to brown adipose tissues, inhibition of adipogenesis and for preventing weight gain in mammals.
Claims3
A method of enhancing energy expenditure in adipose cellular systems of a mammal, said method comprising a) identifying a mammal requiring increase in energy expenditure, and b) administering a composition comprising Cyperus rotundus extract and Passiflora edulis extract comprising Piceatannol, Scirpusin B, Scirpusin A, Cyperusphenol A and Cyperusphenol B, standardized to contain 6-10% w/w total stilbenes to achieve effects of (a) increased expression of PRDM16, PGC-1α and BMP7, (b) induce brown or beige or brite phenotype in white adipocyte depots, or (c) induce enhanced expression of mitochondrial uncoupling protein-1 to result in increased mitochondrial thermogenesis in differentiated brown adipocytes and beige or brite adipocytes.
A method of inhibition of adipogenesis in mammalian cellular systems, said method comprising step of bringing into contact mammalian adipocytes with a composition comprising Cyperus rotundus extract and Passiflora edulis extract comprising Piceatannol, Scirpusin B, Scirpusin A, Cyperusphenol A and Cyperusphenol B, standardized to contain 6-10% w/w total stilbenes to bring about inhibition in adipogenesis.
Dependencies are inferred from the claim text.