Phosphoramidate derivatives of 5-fluoro-2′—deoxyuridine for use in the treatment of cancer
AssigneeNuCana plc
InventorsChristopher McGuigan, Jan Balzarini, Magdalena Slusarczyk, Blanka Gonczy, Paola Murziani
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Abstract
Phosphoramidate derivatives of 5-fluoro-2′-deoxyuridine are disclosed for use in the treatment of cancer, especially in the treatment of cancer where the patient shows resistance, for example, in a patient with cells with a lowered level of nucleoside transporter proteins and/or with nucleoside kinase-deficient cells and/or with mycoplasma-infected cells and/or with cells with a raised level of thymidylate synthase.
Claims10
A method of treating cancer comprising administering intravenously to a human patient in need thereof an effective dose of 5-fluoro-2′-deoxyuridine-5′-O-[1-naphthyl (benzoxy-L-alaninyl)] phosphate, or a pharmaceutically acceptable salt thereof;
- wherein the compound is provided in a sterile aqueous solution or suspension, or
- wherein the compound is presented as a liposome formulation;
- and
- wherein the cancer is responsive to 5-fluorouracil or 5-fluoro-2′-deoxyuridine.
Dependencies are inferred from the claim text.