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US 11,919,888 B2Granted
Neprilysin inhibitors
AssigneeTheravance Biopharma R&D IP, LLC
InventorsMelissa Fleury, Adam D. Hughes
Life of this patent
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Abstract
In one aspect, the invention relates to compounds having the formula: where X, Ra, Rb, R2, and R7 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds are prodrugs of compounds having neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising these compounds; methods of using these compounds; and processes and intermediates for preparing these compounds.
Claims6
A method of making Compound 6N:
- or a pharmaceutically acceptable salt thereof, comprising:
- contacting Compound 2:
- with palladium on carbon and hydrogen gas under conditions sufficient to provide Compound 6N or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.