Method for preparing pregabalin
AssigneeZhejiang Huahai Pharmaceutical Co., Ltd.
InventorsChangming Yang, Pan Guo, Yifeng Wang, Wenling Zhang, Peng Wang
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Abstract
The present invention relates to a method for preparing pregabalin by a biological enzyme method. In particular, the method comprises producing pregabalin B and an R-configuration compound C by using a compound A as a raw material under the action of a biological enzyme; performing configuration inversion of the separated and recovered R-configuration compound C under the action of an isomerase to produce an S-configuration compound D; and producing pregabalin B from the compound D under the action of a biological enzyme.
Claims20
A method for preparing pregabalin comprising:
- reacting a compound of formula (I) in a first solvent with a biological enzyme to produce a target compound of formula (III) and a by-product of formula (II);
- reacting the by-product of formula (II) in a second solvent with an isomerase to perform a configuration inversion to produce a compound of formula (IV);
- reacting the compound of formula (IV) in a third solvent with the biological enzyme to produce the target compound of formula (III);
- wherein:
- R1 and R2 are independently hydrogen or an alkyl group;
- and
- the biological enzyme is a hydrolase.
Dependencies are inferred from the claim text.