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US 11,919,000 B2Granted
Methods and systems for microfluidic screening
Assignee1859, Inc.
InventorsDevon Cayer, Andrew MacConnell, Pavel Chubukov, Ramesh Ramji, Sean Stromberg
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Abstract
Provided are methods and systems useful for screening large libraries of effector molecules. Such methods and systems are particularly useful in microfluidic systems and devices. The methods and systems provided herein utilize encoded effectors to screen large libraries of effectors.
Claims19
A method for screening encoded effectors to identify ion channel modulators, the method comprising:
- (a) providing an encapsulation comprising:
- (i) a cell expressing an ion channel protein;
- (ii) a set of voltage sensor probes;
- and
- (iii) an encoded effector and its corresponding encoding;
- (b) stimulating the ion channel protein of the cell;
- and
- (c) detecting a signal from at least one member of the set of voltage sensor probes,
- wherein the encoded effector is identified as an ion channel modulator based on a difference in the signal relative to a signal from a different encapsulation.
6 more elements
Dependencies are inferred from the claim text.