Varicella zoster virus (VZV) vaccine
AssigneeModernaTX, Inc.
InventorGiuseppe Ciaramella
Life of this patent
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Abstract
Aspects of the disclosure relate to nucleic acid vaccines. The vaccines include at least one RNA polynucleotides having a open reading reading frame encoding at least varicella zoster virus (VZV) antigen. Methods for preparing and using such vaccines are also described.
Claims16
A vaccine composition comprising:(a) a messenger ribonucleic acid (mRNA) comprising an open reading frame encoding a varicella zoster virus (VZV) glycoprotein E (gE) or glycoprotein I (gI);
- and (b) a lipid nanoparticle comprising 20-60 mol % ionizable cationic lipid, 5-25 mol % neutral lipid, 25-55 mol % cholesterol, and 0.5-15 mol % polyethylene glycol (PEG)-modified lipid, wherein the ionizable cationic lipid comprises a compound of Formula (I):
- wherein
- R1 is selected from the group consisting of C5-30 alkyl, C5-20 alkenyl, and —R″M′R′;
- R2 and R3 are independently selected from the group consisting of C1-14 alkyl and C2-14 alkenyl;
- R4 is —(CH2)nQ, wherein Q is —OR, and n is selected from 1, 2, 3, 4, and 5;
- each R5 is H;
- each R6 is H;
- M and M′ are independently selected from —C(O)O— and —OC(O)—;
- R7 is H;
- R is H;
- R′ is selected from the group consisting of C1-18 alkyl and C2-18 alkenyl;
- R″ is selected from the group consisting of C3-14 alkyl and C3-14 alkenyl;
- and
- m is selected from 5, 6, 7, 8, 9, 10, 11, 12, and 13.
A vaccine composition comprising:(a) a chemically modified messenger ribonucleic acid (mRNA) comprising an open reading frame encoding a varicella zoster virus (VZV) glycoprotein E (g E);
- and (b) a lipid nanoparticle comprising 20-60 mol % ionizable cationic lipid, 5-25 mol % neutral lipid, 25-55 mol % cholesterol, and 0.5-15 mol % polyethylene glycol (PEG)-modified lipid, wherein the ionizable cationic lipid comprises a compound of Formula (I):
- wherein
- R1 is selected from the group consisting of C5-30 alkyl, C5-20 alkenyl, and —R″M′R′;
- R2 and R3 are independently selected from the group consisting of C1-14 alkyl and C2-14 alkenyl;
- R4 is —(CH2)nQ, wherein Q is —OR, and n is selected from 1, 2, 3, 4, and 5;
- each R5 is H;
- each R6 is H;
- M and M′ are independently selected from —C(O)O— and —OC(O)—;
- R7 is H;
- R is H;
- R′ is selected from the group consisting of C1-18 alkyl and C2-18 alkenyl;
- R″ is selected from the group consisting of C3-14 alkyl and C3-14 alkenyl;
- and
- m is selected from 5, 6, 7, 8, 9, 10, 11, 12, and 13.
Dependencies are inferred from the claim text.