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US 11,918,639 B2Granted
Methods and compositions for inducing protective immunity against filovirus infection
AssigneesBavarian Nordic A/S, Janssen Vaccines & Prevention B.V., The United States of America as represented by the Secretary, Department of Health and Human Service
InventorsAriane Volkmann, Robin Steigerwald, Ulrike Dirmeier, Maria Grazia Pau, Benoit Christophe Stephan Callendret, Lucy A. Ward
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Abstract
The present invention provides compositions, vaccines and methods for inducing protective immunity against filovirus infection, particularly protective immunity against infection of one or more subtypes of Ebola viruses and Marburg virus.
Claims10
A vaccine combination comprising
- (i) a first composition comprising an immunologically effective amount of an adenovirus vector comprising a nucleic acid encoding an antigenic protein having SEQ ID NO:1, together with a pharmaceutically acceptable carrier;
- and
- (ii) a second composition comprising an immunologically effective amount of an MVA vector comprising a nucleic acid encoding antigenic proteins from four filovirus subtypes having SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:4, and SEQ ID NO:5, together with a pharmaceutically acceptable carrier;
- wherein the first composition is a priming composition and the second composition is a boosting composition.
1 more element
Dependencies are inferred from the claim text.