Methods and treatments using toll-like receptor agonists to mitigate hematopoietic myeloid loss, increase gastrointestinal recovery and reduce tumor growth
AssigneeThe University of North Carolina at Chapel Hill
InventorsJenny P.-Y. Ting, Willie June Brickey, Hao Guo, Cathryn Julia Robbins
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Abstract
Provided herein are methods of mitigating and/or preventing side effects from chemotherapy and/or radiotherapy in a subject by administering a therapeutically effective amount of a toll-like receptor 2/6 (TLR 2/6) ligand, including fibroblast-stimulating lipopeptide 1 (FSL-1). Methods of treating and/or preventing gastrointestinal disorders are also disclosed. Additionally, methods of increasing granulocyte colony-stimulating factor (G-CSF) production in a subject undergoing a medical treatment, including administering FSL-1 compositions, are provided.
Claims5
A method of mitigating and/or preventing side effects from chemotherapy in a subject, the method comprising
- administering to the subject a therapeutically effective amount of a fibroblast-stimulating lipopeptide 1 (FSL-1),
- wherein side effects from chemotherapy are substantially mitigated and/or prevented in the subject.
Dependencies are inferred from the claim text.