Bacteriophage therapy
AssigneesFerring B.V., Institut Pasteur
InventorsPascal Danglas, Laurent Debarbieux
Life of this patent
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Abstract
The subject invention provides a pharmaceutical composition comprising: (i) at least one bacteriophage strain(s) capable of producing a lytic infection in an adherent-invasive Escherichia coli strain; and (ii) a pharmaceutically acceptable carrier; for the treatment of inflammatory bowel disease. The subject invention further provides a method of treating inflammatory bowel disease comprising administering to a subject in need thereof at least one bacteriophage strain capable of producing a lytic infection in an adherent-invasive Escherichia coli strain thereby treating the subject. The subject invention also provides new bacteriophage strains.
Claims10
A pharmaceutical composition comprising bacteriophages capable of producing a lytic infection in an adherent-invasive Escherichia coli strain, wherein the composition comprises:
- (a) bacteriophages of strain P2 deposited with the French National Collection of Microorganisms at the Institut Pasteur under Accession Number CNCM 1-4695, or a variant thereof, wherein the variant has the same lytic activity and at least 80% sequence identity on at least 70% of length as said deposited bacteriophage strain P2;
- (b) bacteriophages of strain P8 deposited with the French National Collection of Microorganisms at the Institut Pasteur under Accession Number CNCM 1-4700, or a variant thereof, wherein the variant has the same lytic activity and at least 80% sequence identity on at least 70% of length as said deposited bacteriophage strain P8;
- (c) bacteriophages of strain CLB P2 deposited with the French National Collection of Microorganisms at the Institut Pasteur under Accession Number CNCM 1-4675 or a variant thereof, wherein the variant has the same lytic activity as said deposited bacteriophage strain CLB P2, and
- (d) a pharmaceutically acceptable carrier comprising one or more pharmaceutically acceptable auxiliary agents selected from matrix-forming agents, thickeners, binders, lubricants, pH adjusting agents, protecting agents, viscosity enhancers, wicking agents, disintegrants, surfactants, anti-oxidants, wetting agents, colorants, flavoring agents, taste-masking agents, sweeteners, and preservatives.
Dependencies are inferred from the claim text.