Probiotic bacterial strains producing antimicrobial proteins and compositions comprising these for use in the treatment of diarrheal and other microbial diseases
AssigneeCrigasseni AG
InventorFederico Graf
Life of this patent
Estimating the term…
Abstract
The present invention is directed to a bacterial, preferably probiotic bacterial peptidoglycan hydrolase (PGH), a peptidoglycan hydrolase (PGH)-comprising bacterial, preferably probiotic bacterial strain or a peptidoglycan hydrolase (PGH)-comprising composition for use in the therapeutic or prophylactic treatment of a bacterial infection, preferably for the treatment of a bacterial infection resulting in diarrhea. Further aspects of the present invention relate to corresponding methods for preparing a medicament and to a corresponding method of treatment.
Claims22
A method for the prophylaxis and/or treatment of a Clostridium difficile infection in a patient in need of such treatment or prophylaxis, comprising the steps of:
- administering an effective amount of a peptidoglycan hydrolase (PGH)-secreting probiotic bacterial strain that includes Lactococcus lactis CCOS 949 (DSM 32294), Lactobacillus gasseri CCOS 960 (DSM 32296), Lactobacillus plantarum CCOS 893 (DSM 32352), Lactobacillus johnsonii CCOS 824 (CCOS 824), Lactobacillus paracasei subsp. Paracasei CCOS 1205 (CCOS 1205), Lactobacillus paracasei subsp. Paracasei CCOS 1201 (CCOS 1201), or Lactobacillus rhamnosus CCOS 965 (CCOS 965),
- wherein the peptidoglycan hydrolase (PGH) is alpha-N-acetylglucosaminidase, beta-N-acetylglucosaminidase, or a combination thereof, and the method effectuates the prophylaxis and/or treatment of the Clostridium difficile infection in the patient.
A method for the prophylaxis and/or treatment of a Clostridium difficile infection in a patient in need of such treatment or prophylaxis, comprising the steps of:
- administering an effective amount of a peptidoglycan hydrolase (PGH)-secreting probiotic bacterial strain that includes Lactobacillus gasseri CCOS 960 (DSM 32296), Lactobacillus plantarum CCOS 893 (DSM 32352), Lactobacillus johnsonii CCOS 824 (CCOS 824), Lactobacillus paracasei subsp. Paracasei CCOS 1205 (CCOS 1205), Lactobacillus paracasei subsp. Paracasei CCOS 1201 (CCOS 1201), or Lactobacillus rhamnosus CCOS 965 (CCOS 965),
- wherein the peptidoglycan hydrolase (PGH) is alpha-N-acetylglucosaminidase, beta-N-acetylglucosaminidase, or a combination thereof, and the method effectuates the prophylaxis and/or treatment of a Clostridium difficile infection in the patient.
Dependencies are inferred from the claim text.