Phosphate derivatives and use thereof

A compound with a formula (II),

• or a tautomer, mesomer, racemate, enantiomer, and diastereoisomer thereof, or a mixture form thereof, or a pharmaceutically acceptable salt thereof, wherein
• L is selected from a group consisting of C1-C10 alkyl, cycloalkyl, cycloalkylalkyl, alkylcycloalkyl, aryl, arylalkyl, alkylaryl, heteroaryl, heteroarylalkyl, alkylheteroaryl, alkenyl, alkynyl, a C3-C15 linear or branched chain containing an O, or S atom, a linear or branched chain consisting of repeating units of C1-C15 linear or branched chains containing O, or S atoms, bisaryl, bisheteroaryl, aryl-heteroaryl group or heteroaryl-aryl group, and bisaryl and bisheteroaryl linked by O, S or
• wherein the alkyl, the cycloalkyl, the heterocyclyl, the aryl or the heteroaryl may be each independently substituted by one or more substituents selected from a group consisting of hydroxyl, halogen, alkyl, alkoxyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl;
• K is selected from
• with B selected from a group consisting of
• R1 and R2 are each independently selected from a group consisting of hydrogen, alkyl, cycloalkyl, hydroxyalkane, alkoxylalkyl, alkoxylcycloalkyl, cycloalkylalkyl, alkylcycloalkyl, alkenyl, alkynyl, amino, hydroxyl, mercapto, carboxyl, alkoxyl, cycloalkoxyl, haloalkyl, cyano, thioalkyl, sulfo, sulfonyl, sulfinyl, phosphate, alkylphosphonate, arylphosphate, and arylphosphonate, wherein the alkyl, the cycloalkyl, the heterocyclyl, the aryl, or the heteroaryl may be each independently substituted by one or more substituents selected from a group consisting of hydroxyl, halogen, alkyl, alkoxyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl, or may be null;
• R3 and R4 are each independently selected from a group consisting of hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, alkylcycloalkyl, aryl, arylalkyl, alkylaryl, heteroaryl, heteroarylalkyl, alkylheteroaryl, heterocyclyl, heterocyclylalkyl, alkylheterocyclyl, alkenylalkyl, and alkynylalkyl, wherein the alkyl, the cycloalkyl, the cycloalkylalkyl, the alkylcycloalkyl, the aryl, the arylalkyl, the alkylaryl, the heteroaryl, the heteroarylalkyl, the alkylheteroaryl, the heterocyclyl, the heterocyclylalkyl, the alkylheterocyclyl, the alkenylalkyl, or the alkynylalkyl is not substituted or is substituted by one or more substituents, each of which is selected from a group consisting of alkyl, cycloalkyl, cycloalkylalkyl, alkylcycloalkyl, aryl, arylalkyl, alkylaryl, heteroaryl, heteroarylalkyl, alkylheteroaryl, heterocyclyl, heterocyclylalkyl, alkylheterocyclyl, alkenyl, alkynyl, amino, hydroxyl, mercapto, carboxyl, alkoxyl, cycloalkoxyl, haloalkyl, alkoxycarbonyl, acyloxy, amido, ureido, alkylsulfonyl, arylsulfonyl, haloalkyl, halogen, cyano, nitro, nitroso, thiocyano, isothiocyano, thioalkyl, sulfo, phosphate, phosphonate, alkylphosphate, alkylphosphonate, arylphosphate, and arylphosphonate;
• or R3 and R4 together with a nitrogen atom for linking R3 and R4 form heterocyclyl, which is a monocyclic ring, a bicyclic ring or a tricyclic ring, or a fused ring, a bridge ring or a spiro-ring, wherein the heterocyclyl comprises at least one N atom or one, two or three heteroatoms optionally selected from N, S and O, and is not substituted or is optionally substituted by one or more substituents, each of which is independently selected from a group consisting of alkyl, cycloalkyl, cycloalkylalkyl, alkylcycloalkyl, aryl, arylalkyl, alkylaryl, heteroaryl, heteroarylalkyl, alkylheteroaryl, heterocyclyl, heterocyclylalkyl, alkylheterocyclyl, alkenyl, alkynyl, amino, hydroxyl, mercapto, carboxyl, alkoxyl, cycloalkoxyl, haloalkyl, alkoxycarbonyl, acyloxy, amido, ureido, alkylsulfonyl, arylsulfonyl, haloalkyl, halogen, cyano, nitro, nitroso, thiocyano, isothiocyano, thioalkyl, sulfo, phosphate, phosphonate, alkylphosphate, alkylphosphonate, arylphosphate, and arylphosphonate, which are used as a substituent alone or in a free combination thereof,
• A1 and A2 are each independently selected from a group consisting of Li, Na, K, Cs, and a corresponding positive ion thereof, or A1 and A2 form Ca, Mg, Al, Sc, Ti, Cr, Co, Fe, Ni, Cu, Zn, Cd, Hg, and a corresponding positive ion thereof, collectively;
• E is selected from a group consisting of oxygen and C(R1R2);
• R5 and R6 are each independently selected from a group consisting of a hydrogen atom, halogen, alkyl, alkoxyalkyl, cycloalkyl, alkoxycycloalkyl, hydroxyalkyl, hydroxycycloalkyl, heterocyclyl, aryl and heteroaryl, wherein the alkyl, the cycloalkyl, the heterocyclyl, the aryl or the heteroaryl may be each independently substituted by one or more substituents selected from a group consisting of hydroxyl, halogen, alkyl, alkoxyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl;
• or R5 and R6 may form a 3-membered to 8-membered ring, which may contain 1 to 2 heteroatoms of O, N and/or S;
• R7 and R8 are each independently selected from a group consisting of a hydrogen atom, alkyl, hydroxyalkyl, cycloalkyl, alkoxyalkyl, alkoxycycloalkyl, heterocyclyl, aryl and heteroaryl, wherein the alkyl, the cycloalkyl, the heterocyclyl, the aryl or the heteroaryl may be each independently substituted by one or more substituents selected from a group consisting of hydroxyl, halogen, alkyl, alkoxy, cycloalkyl, heterocyclyl, aryl and heteroaryl;
• R9 is hydrogen
• R10 is selected from a group consisting of a hydrogen atom, halogen, alkane, cycloalkyl, heterocyclyl, aryl, and heteroaryl, or is null, wherein the alkane, the cycloalkyl, the heterocyclyl, the aryl, or the heteroaryl may be each independently substituted by one or more substituents selected from a group consisting of hydroxyl, halogen, alkyl, alkoxy, cycloalkyl, heterocyclyl, aryl, and heteroaryl;
• n1 is selected from a group consisting of 0, 1, 2, 3, 4, 5, 6, 7, and 8;
• n2 is selected from a group consisting of 1, 2, 3, 4, 5, and 6;
• n3 is selected from a group consisting of 1, 2, and 3;
• n4 is selected from a group consisting of 0, 1, 2, 3, and 4;
• n5 is selected from a group consisting of 0, 1, 2, and 3;
• and
• n6 is selected from a group consisting of 1, 2, and 3.