Deuterium-enriched pioglitazone
AssigneePoxel
InventorAnthony W. Czarnik
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Abstract
The present application describes deuterium-enriched pioglitazone, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.
Claims9
A method of treating non-alcoholic steatohepatitis, comprising administering a therapeutically effective amount of a deuterium-enriched compound to a patient in need thereof to treat the non-alcoholic steatohepatitis, wherein the deuterium-enriched compound is
- or a pharmaceutically acceptable salt thereof, wherein
- R1 and R2 are independently selected from H and D, and R3-R20 are H;
- wherein the abundance of deuterium in R1 is at least 30% and the abundance of deuterium in R2 is at least 30%.
A method of treating non-alcoholic steatohepatitis, comprising administering a therapeutically effective amount of a deuterium-enriched compound to a patient in need thereof to treat the non-alcoholic steatohepatitis, wherein the deuterium-enriched compound is
- or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are independently selected from H and D, and R3-R20 are H;
- wherein the abundance of deuterium in R1 is at least 30% and the abundance of deuterium in R2 is at least 90%.
Dependencies are inferred from the claim text.