High-voltage pulse ablation systems and methods

A method of administering an ablation treatment to a patient's skin, the method comprising:

• placing a return pad at a location on the patient's skin;
• placing an ablation assembly at a patient target tissue having a tissue thickness, the ablation assembly comprising a first electrode mechanism and a second electrode mechanism, wherein the first electrode mechanism and the second electrode mechanism are spaced linearly along the ablation assembly, wherein the first electrode mechanism and the second electrode mechanism each comprise one or more coagulation electrodes and one or more stimulation electrodes;
• applying a high voltage pulse regimen to the tissue between the first electrode mechanism and the second electrode mechanism with the ablation assembly, wherein the pulse regimen comprises a plurality of 1000-2000 volt pulses each having a duration of between about 0.02 msec and about 0.1 msec, and wherein the pulses are delivered by the stimulation electrodes at a frequency comprising a pulse number within a range from about 5 to about 50 pulses discharged over a time interval within a range from about 1 to about 60 seconds;
• and
• creating a lesion within the patient target tissue, the lesion having a width of about twice of the tissue thickness.