Fused pentacyclic imidazole derivatives

A compound represented by formula (IC), or an N-oxide thereof, or a pharmaceutically acceptable salt thereof,

• wherein
• X-Q- represents —O—, —O—C(O)—, —O—C(CH—CN)—, —S—, —SO—, —SO2—;
• or —N(Rg)—, —N(Rf)—CO, —N(Rf)—SO2—, —O—CH2—, —CH2—S—, —CH2—SO—, —CH2—SO2—, —N(Rg)—CH2—, —N(Rf)—C(S)—, —N═S(O)(CH3)—, —O—C(═CH2)— or —S(═N—CN)—, any of which groups may be optionally substituted by one or more substituents selected from fluoro, methyl, carboxy, trifluoromethyl, methylcarbonyl, deuterated methyl, ethoxycarbonyl, hydroxyisopropyl, and hydroxymethyl;
• Z represents methylene;
• R1 represents halogen or cyano;
• or aryl, heteroaryl, (C3-7)cycloalkyl-heteroaryl, (C3-7)heterocycloalkyl-heteroaryl, (C4-9)heterobicycloalkyl-heteroaryl, (C3-7)heterocycloalkyl, (C3-7)heterocycloalkenyl, or (C3-7)heterocycloalkenyl-aryl, any of which groups may be optionally substituted by one or more substituents selected from halogen, cyano, cyano(C1-6)alkyl, C1-6 alkyl, difluoromethyl, trifluoromethyl, hydroxy, (hydroxy)(C1-6)alkyl, amino, (amino)(C1-6) alkyl, C1-6 alkoxy, (C1-6) alkoxy(C1-6)alkyl, C2-6 alkylcarbonyl, C2-6 alkoxycarbonyl, (C2-6) alkoxycarbonyl-amino-C1-6 alkyl, phosphate(C1-6)alkyl, C1-6 alkylthio, C1-6 alkylsulphonyl, oxo, (C1-6)alkylsulphoximinyl, (C1-6)alkylsulphinyl-amino-, di(C1-6)alkylamino (C1-6)alkyl, (C2-6)alkylcarbonylamino(C1-6)alkyl, di(C1-6)alkenylamino (C1-6)alkyl, (C2-6)alkylcarbonylamino(C1-6)alkyl, C1-6 alkylsulphonyl-amino-C1-6 alkyl, tetrahydrofuranyl, sulphate(C1-6)alkyl, and carboxy-(C1-6)alkyl-carbonyloxy-(C1-6)alkyl;
• R2 represents hydrogen or halogen;
• R3 and R4 independently represent hydrogen, halogen or trifluoromethyl;
• or C1-6 alkyl;
• R5 represents halogen, —ORa, difluoromethoxy or trifluoromethoxy;
• R6 represents hydrogen, halogen or trifluoromethyl;
• R7 represents hydrogen or trifluoromethyl;
• R8 represents hydrogen, halogen or trifluoromethyl;
• R12 represents C1-6 alkyl;
• Ra represents C1-6 alkyl;
• Rf represents hydrogen;
• or C1-6 alkyl, which group may be optionally substituted by one or more substituents selected from halogen or C1-6 alkyl;
• and
• R9 represents hydrogen;
• or C1-6 alkyl, —CO—(C1-6)alkyl, —SO2—(C1-6)alkyl, —CO—(C3-7)heterocycloalkyl, —SO2—(C3-7)cycloalkyl, —SO2-aryl, —SO2-heteroaryl, heteroaryl or (C2-6)alkoxycarbonyl, any of which groups may be optionally substituted by one or more substituents selected from halogen or C1-6 alkyl 1.