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US 11,912,705 B2Granted
Cathinone derivatives, pharmaceutical formulations, and methods
AssigneeThe Corporation of Mercer University
InventorsClinton E. Canal, Nader Moniri, Yiming Chen
Life of this patent
Estimating the term…
Abstract
Compounds, such as cathinone derivatives, and pharmaceutical formulations that include the compounds. The compounds may have a first selectivity for a first receptor subtype that is at least 10 times greater than a second selectivity for a second receptor subtype from the same class of receptors. Methods of treating patients, which may include administering to a patient a pharmaceutical formulation that includes a compound, such as a cathinone derivative.
Claims42
A compound of formula (I), formula (II), or formula (III), or a salt of formula (I), formula (II), or formula (III):
- wherein R1 is a C1-C10 hydrocarbyl comprising a nitrogen atom;
- wherein R2, R3, R4, R5, and R6 are independently selected from the group consisting of hydrogen, methyl, methoxy, hydroxy, a first halogen, and a C1-C6 hydrocarbyl comprising a covalent bond between R2 and R3, R3 and R4, R4 and R5, or R5 and R6;
- and
- wherein X is selected from the group consisting of hydrogen, methyl, ethyl, hydroxy, and a second halogen;
- and
- wherein (i) R1 is an 8-methyl-8-azabicyclo[3.2.1]octanyl, or (ii) the compound of formula (I), formula (II), or formula (III) is a structure, or a salt thereof, selected from the group consisting of—
3 more elements
Dependencies are inferred from the claim text.