Aryl alkynamide derivatives
AssigneesAstellas Pharma Inc., Mitobridge, Inc.
InventorsJunko Maeda, Ikumi Kuriwaki, Kai Kitamura, Yumi Yamashita, Kenichi Kakefuda, Akio Kamikawa, Kenji Negoro, Wataru Hamaguchi, Ryushi Seo, Jeffrey Ciavarri
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Abstract
[Problem] A compound which is useful as a STING inhibitor is provided. [Means for Solution] The present inventors have found aryl alkynamide derivatives having an inhibitory action on STING. The aryl alkynamide derivatives of the present invention have an inhibitory action on STING and can be used as an agent for treating an autoimmune disease, a neurodegenerative disease, a type I interferonopathy and/or other STING-mediated disease.
Claims19
A compound of formula (I) or a salt thereof:
- wherein,
- Ring A is phenyl,
- Ring B is formula (V):
- X is CH or N,
- Ra1, Ra2 and Rb1 are H,
- Rb2 is halogeno-C1-6 alkyl,
- R1 is H,
- R2 is C1-6 alkyl which is substituted by one or two R3,
- or, R1 and R2 are linked to each other to form azetidinyl, pyrrolidinyl, piperidinyl or thiomorpholinyl together with the nitrogen atom to which R1 and R2 are attached, wherein the azetidinyl, pyrrolidinyl, piperidinyl or thiomorpholinyl may be optionally substituted with one or two R7,
- each R3 is independently —OH or —C(═O)—NH2, and
- each R7 is independently —C1-6 alkylene-OH, —OH, —C(═O)—NH2, oxo or imino.
Dependencies are inferred from the claim text.