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US 11,912,646 B2Granted
Transmembrane pores formed by aromatic oligoamide foldamers and uses of same
AssigneeThe Research Foundation for The State University of New York
InventorBing Gong
Life of this patent
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Abstract
Provided are aromatic oligoamide foldamers and self-assembled compositions of the same. The aromatic oligoamide foldamers and compositions can form tube-like structures that can form pores in membranes. The pores can be used to transport ions and molecules, such as, for example, cryoprotective agents or therapeutic agents, through the membrane. The tube-like structures exhibit desirable stability at low temperatures.
Claims21
A method of forming a pore comprising:
- contacting a vesicle having a membrane with a compound or a plurality of compounds having the following structure:
- wherein
- R and R′ are independently at each occurrence chosen from methyl groups, isopropyl groups, ether groups, and oligoether groups;
- X is an acyl group;
- Y is —NHCH3, —NHCH2CH3, —NHR″, —OCH3, —OCH2CH3, —OC(CH3)3, or —OR″, wherein R″ is a linear or branched alkyl group;
- and n=3 to 64,
- wherein the compound or the plurality of compounds form a pore in the membrane.
4 more elements
Dependencies are inferred from the claim text.