Back to results
US 11,911,719 B2Granted
Devices and methods for the integrated filtration, drying, and mechanical processing of active pharmaceutical ingredients
AssigneeMassachusetts Institute of Technology
InventorsDavid Brancazio, Allan S. Myerson, Mohammad A. Azad, Gregory J. Hammersmith, Gerard Capellades Mendez, Clemence Neurohr, Kersten Rapp, Naomi Elizabeth Barbara Briggs
Life of this patent
Estimating the term…
Abstract
Devices and methods for filtering, drying, and mechanically processing active pharmaceutical ingredients are generally described.
Claims19
A method, comprising:
- rotating an edge comprising a plurality of protrusions extending toward a filtration medium such that the edge sweeps at least a portion of a facial area of the filtration medium in a clockwise direction;
- and
- rotating the edge such that the edge sweeps at least a portion of the facial area of the filtration medium in a counterclockwise direction;
- wherein the edge comprises at least 20 protrusions having a protruding dimension of greater than or equal to 1 mm and less than or equal to 2 cm;
- wherein the at least 20 protrusions have an average spacing of greater than or equal to 1 mm and less than or equal to 1 cm;
- wherein the rotating in the clockwise direction and/or the counterclockwise direction breaks up solid material having maximum cross-sectional dimensions of greater than or equal to 100 micrometers and less than or equal to 10 millimeters, forming a powder;
- and
- wherein at least 90%, by mass, of the powder has a particle size of less than 500 micrometers.
5 more elements
A method of processing a cake comprising an active pharmaceutical ingredient, the method comprising:
- rotating an edge comprising a plurality of protrusions extending toward a filtration medium such that the edge sweeps at least a portion of the filtration medium in a clockwise direction;
- and
- rotating the edge such that the edge sweeps at least a portion of the filtration medium in a counterclockwise direction;
- wherein the rotating in the clockwise direction and/or the counterclockwise direction breaks up agglomerates and/or lumps formed from the cake comprising the active pharmaceutical ingredient, the agglomerates and/or lumps having maximum cross-sectional dimensions of greater than or equal to 100 micrometers and less than or equal to 10 millimeters, forming powder from the cake;
- wherein at least 90%, by mass, of the powder has a particle size of less than 500 micrometers;
- wherein the edge comprises at least 20 protrusions having a protruding dimension of greater than or equal to 1 mm and less than or equal to 2 cm;
- and
- wherein the at least 20 protrusions have an average spacing of greater than or equal to 1 mm and less than or equal to 1 cm.
5 more elements
Dependencies are inferred from the claim text.