Reverse thermal gels and their use as vascular embolic repair agents

A reversible thermal gel polymer formulation, comprising:

• (a) reversible thermal gel polymers, wherein each of the polymers independently comprise:
• a first polymer block comprising first repeating units, wherein each of the first repeating units of the first polymer block independently comprise a hydrophilic group;
• and
• a second polymer block comprising second repeating units, wherein each of the second repeating units of the second polymer block independently comprise a thermosensitive group;
• wherein:
• the first polymer block and the second polymer block are directly or indirectly covalently linked;
• wherein:
• each of the polymers is independently is characterized by the formula (FX4):
• Y is selected from the group consisting of —OH, a radiopaque group, and a targeting ligand;
• L3, if present, is selected from the group consisting of a single bond, —(CH2)q—, —(HCCH)q—, —(CH2CH2X)q—, —(CHXH)q—, —X—, —NR5—, —CX—, —CXX—, —XCX—, —XCX(CH2)qCXX—, —CXNR5—, —NR5CX—, —XCXNR5—, —NR5CXX—, —CX(CH2)qCR5CN—, —(CH2)qX(CH2)r—, —(CH2)qXX(CH2)r, —(CH2)qNR5(CH2)r—, —(CH2)qCX(CH2)r—, —(CH2)qCXX(CH2)r—, —(CH2)qCXNR5(CH2)r—, —(CH2)qNR5CX(CH2)r—, —(CH2)qXCXNR5(CH2)r—, and —(CH2)qNR5CXNR6(CH2)r—;
• X is O or S;
• W2, if present, is selected from the group consisting of a single bond, —(CH2)q—, —(HCCH)q—, —(CH2CH2X)q—, —(CHXH)q—, —X—, —CXX—, —XCX—, —CX—, —XCX(CH2)qCXX—, and —NR11—;
• W2, if present, is selected from the group consisting of a single bond, —(CH2)q—, —(HCCH)q—, —(CH2CH2X)q—, —(CHXH)q—, —X—, —CXX—, —XCX, —CX—, —XCX(CH2)qCXX—, and —NR11—;
• each of R1, R2, R3, and R4 is independently selected from the group consisting of hydrogen, halide, and C1-C5 alkyl;
• each of a, b and c is independently 0 or 1;
• each of q and r is an integer independently selected from the range of 1 to 10:
• z is an integer selected from the range of 0 to 4;
• m is an integer selected from the range of 1 to 10,000;
• n is an integer selected from the range of 1 to 1,000;
• p is an integer selected from the range of 1 to 1,000;
• and
• each of R5, R6 and R11 is independently selected from the group consisting of hydrogen, C1-C10 alkyl, C5-C10 aryl, and C5-C10 heteroaryl;
• and
• (b) a solvent;
• wherein said reversible thermal gel polymers are dissolved in said solvent and have a concentration in the solvent selected from the range of 2% to 50% w/v;
• and
• wherein the polymer formulation is characterized by a viscosity less than or equal to 1,500 cP.