Anti-parasitic immunological compositions
AssigneesPrommune, Inc., Board of Regents of the University of Nebraska
InventorsPaul Davis, Samer Al-Murrani
Life of this patent
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Abstract
Anti-parasitic compounds and uses thereof. Compounds comprising a C-terminal peptide adjuvant conjugated to an N-terminal peptide antigen via a protease-cleavable linker, said peptide adjuvant comprising a peptide analog of C5a, wherein said peptide antigen comprises an antigenic epitope of a parasitic organism, such as T. gondii. Methods of therapeutic or prophylactic treatment of a parasitic infections.
Claims11
A composition for inducing an immune response to Toxoplasma gondii infection, the composition comprising a plurality of peptides dispersed in a pharmaceutically acceptable carrier, said peptides each comprising an N-terminal peptide antigen conjugated to a C-terminal peptide adjuvant via a protease-cleavable linker,
- wherein said N-terminal peptide antigen is selected from the group consisting of SFKDILPKLSENPWQ (SEQ ID NO:19), EEVIDTMKSMQRDEE (SEQ ID NO:20), CAELCDPSNKPGHLL (SEQ ID NO:21), KRVTCGYPESGPVNL (SEQ ID NO:22), DRRPLHPGSVNEFDF (SEQ ID NO:23), and GLVAAALPQFATAAT (SEQ ID NO:24), and
- wherein said C-terminal peptide adjuvant is EP67 YSFKDMP(MeL)aR (SEQ ID NO:2),
- said plurality of peptides comprising at least two or more different peptides each having a different N-terminal peptide antigen.
Dependencies are inferred from the claim text.