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US 11,911,369 B2Granted
Prodrugs of riluzole and their method of use
AssigneeBiohaven Therapeutics Ltd.
InventorsJay Edward Wrobel, Allen B. Reitz, Jeffery Claude Pelletier, Garry Robert Smith, Haiyan Bian
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Abstract
Pharmaceutical compositions of the invention include substituted riluzole prodrugs useful for the treatment of cancers including melanoma, breast cancer, brain cancer, and prostate cancer through the release of riluzole. Prodrugs of riluzole have enhanced stability to hepatic metabolism and are delivered into systemic circulation by oral administration, and then cleaved to release riluzole in the plasma via either an enzymatic or general biophysical release process.
Claims9
A pharmaceutical composition comprising:
- (i) compound having formula (I):
- including enantiomers, diastereomers, hydrates, solvates, pharmaceutically acceptable salts, and complexes thereof, wherein:
- R1 is CR10aR10bNR11R12,
- R10a and R10b are hydrogen,
- R11 is hydrogen,
- R12 is COCR13aR13bNR15aR15b,
- R13a and R13b are hydrogen,
- R15a is hydrogen, and
- R15b is C1-C6 alkyl;
- and
- (ii) a pharmaceutically acceptable carrier.
8 more elements
Dependencies are inferred from the claim text.