# US 11,908,154 B2 · System and method for evaluating tumor stability > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,908,154 B2 - Document ID: US11908154B2 - Status: Granted - Kind: B2 - Application number: 17/167,830 - Filed: 2021-02-04 - Published: 2022-08-04 - Granted: 2024-02-20 - Earliest claimed: 2021-02-04 - Assignees: Fibonacci Phyllotaxis Inc. - Applicants: Fibonacci Phyllotaxis Inc. - Inventors: Colin Paul Spears; Stephanie Brower - Web page: https://patentgrep.com/patent/US11908154B2 ## CPC - G06T 7/62: of area, perimeter, diameter or volume - A61B 5/0022: {Monitoring a patient using a global network, e.g. telephone networks, internet} - A61B 5/0077: {Devices for viewing the surface of the body, e.g. camera, magnifying lens} - A61B 5/103: Measuring devices for testing the shape, pattern, {colour,} size or movement of the body or parts thereof, for diagnostic purposes (measuring instruments specially adapted for dentistry A61C19/04) - A61B 5/1075: {for measuring dimensions by non-invasive methods, e.g. for determining thickness of tissue layer (A61B8/0858 takes precedence)} - A61B 5/444: {Evaluating skin marks, e.g. mole, nevi, tumour, scar} - A61B 5/4842: {Monitoring progression or stage of a disease} - A61B 5/6898: {Portable consumer electronic devices, e.g. music players, telephones, tablet computers} - A61B 5/742: {using visual displays (displays for heart-related electrical signals, e.g. ECG, A61B5/339)} - A61B 5/7425: {Displaying combinations of multiple images regardless of image source, e.g. displaying a reference anatomical image with a live image} - G06T 7/0014: {using an image reference approach} - G06T 7/0016: {involving temporal comparison} - G06T 2207/10116: X-ray image - G06T 2207/30088: Skin; Dermal - G06T 2207/30096: Tumor; Lesion - G06T 2207/30204: Marker - G06T: IMAGE DATA PROCESSING OR GENERATION, IN GENERAL - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract A device for identifying a size doubling number of a lesion, having: a planar surface defining a data portion that includes data zones, including: a first zone that defines first zone arcs distributed in a concentric configuration, the first zone arcs defining first mutually unique radii, ranging from a first minimum radius to a first maximum radius; the first zone includes first zone size markers, respectively positioned adjacent ones of the first zone arcs, and the first zone size markers respectively identify the size doubling number of the clinical lesion having a size that corresponds to a respective one of the first zone arcs, the size doubling number being one or more of a volume doubling number, an area doubling number and a radius doubling number. ## Claims ### Claim 1 A device for identifying a-size doubling numbers (SDNs) of a clinical lesion relative to a predetermined size of the clinical lesion, the device comprising: a planar surface including a first planar surface end, the planar surface extending longitudinally aft from the first planar surface end to a second planar surface end; the planar surface defining a data portion first end that is adjacent the first planar surface end, and a data portion extending longitudinally aft from the data portion first end to a data portion second end, wherein the data portion includes data zones, including: a first zone defining a first zone first end that is adjacent the data portion first end, the first zone extending longitudinally aft from the first zone first end to a first zone second end, wherein: the first zone defines first zone arcs, the first zone arcs being distributed in a concentric configuration, the first zone arcs defining first mutually unique radiuses R1, ranging from a first minimum radius R1min of a first zone first arc to a first maximum radius R1max of a first zone last circle, and wherein a concentric center of the first zone arcs is adjacent the first zone first end; the first zone arcs are successively larger from each other by a predetermined multiplication factor; the first zone includes first zone size markers, respectively positioned adjacent ones of the first zone arcs, and the first zone size markers respectively identify the size doubling numbers (SDNs) of the clinical lesion having a size that corresponds to a respective one of the first zone arcs, the first zone arcs are laterally aligned and longitudinally spaced apart from each other within the first zone, between the concentric center and the first zone second end; and the first zone first arc represents 2{circumflex over ( )}n1 volume doublings relative to a single tumor cell of the clinical lesion, and the first zone last arc represents 2{circumflex over ( )}m1 volume doublings relative to the single tumor cell, where m1=n1+c1, wherein c is the number of circles in the first zone arcs, and wherein n1=30, and c1=10 or greater; and the data zones include: a second zone that is laterally adjacent the first zone, the second zone defining a second zone first end that is longitudinally aligned with the first zone, the second zone extending longitudinally aft from the second zone first end to a second zone second end, wherein: the second zone defines a graduated line gauge and defines second zone size markers, wherein the second zone size markers identify one or more of radius R, area A, volume V, and the SDN of the clinical lesion. ### Claim 2 (depends on 1) The device of claim 1, including: a third zone defining a third zone first end 320 adjacent to the first zone second end, and the third zone extending longitudinally aft from the third zone first end to a third zone second end, wherein: the third zone defines third zone circles and includes third zone size markers, the third zone circles being distributed in a non-overlapping configuration and defining second mutually unique radiuses R2 ranging from a second minimum radius R2min of a third zone first circle to a second maximum radius R2max of a third zone last circle; each successively larger circle in the third zone circles is larger than each successively smaller circle in the third zone circles by the first multiplication factor; the first minimum radius R1min of the first zone arcs is the same as or greater than the second maximum radius R2max of the third zone circles; the third zone size markers identify one or more of radius R, area A, volume V and the size doubling number of the clinical lesion having a size that corresponds to a respective one of the third zone circles. ### Claim 3 (depends on 2) The device of claim 2, wherein: wherein the third zone first circle represents 2{circumflex over ( )}n2 volume doublings of the single tumor cell relative to the clinical lesion, and the third zone last circle represents 2{circumflex over ( )}m2 volume doublings relative to the single tumor cell, where m2=n2+c2, wherein c2 is the number of circles in the third zone circles, and wherein n2=24, and c2=7 or more. ### Claim 4 (depends on 1) The device of claim 1, wherein: the device defines a ruler that is at least partially transparent, wherein the planar surface is approximately rectangular and is smaller in a lateral direction L1 than a longitudinal direction L2. ### Claim 5 A device for identifying a-size doubling numbers (SDNs) of a clinical lesion relative to a predetermined size of the clinical lesion, the device comprising: a planar surface including a first planar surface end, the planar surface extending longitudinally aft from the first planar surface end to a second planar surface end; the planar surface defining a data portion first end that is adjacent the first planar surface end, and a data portion extending longitudinally aft from the data portion first end to a data portion second end, wherein the data portion includes data zones, including: a first zone defining a first zone first end that is adjacent the data portion first end, the first zone extending longitudinally aft from the first zone first end to a first zone second end, wherein: the first zone defines first zone arcs, the first zone arcs being distributed in a concentric configuration, the first zone arcs defining first mutually unique radiuses R1, ranging from a first minimum radius R1min of a first zone first arc to a first maximum radius R1max of a first zone last circle, and wherein a concentric center of the first zone arcs is adjacent the first zone first end; the first zone arcs are successively larger from each other by a predetermined multiplication factor; the first zone includes first zone size markers, respectively positioned adjacent ones of the first zone arcs, and the first zone size markers respectively identify the size doubling numbers (SDNs) of the clinical lesion having a size that corresponds to a respective one of the first zone arcs, wherein the device further includes: a slider configured to slide longitudinally along the planar surface, the slider defining a laterally extending marker, wherein a size measurement of the clinical lesion is obtained by positioning the laterally extending marker so that it laterally extends as a tangent from one of the first zone arcs corresponding to a size of the clinical lesion to a respective one of the second zone size markers, the first zone arcs are laterally aligned and longitudinally spaced apart from each other within the first zone, between the concentric center and the first zone second end; and the first zone first arc represents 2{circumflex over ( )}n1 volume doublings relative to a single tumor cell of the clinical lesion, and the first zone last arc represents 2{circumflex over ( )}m1 volume doublings relative to the single tumor cell, where m1=n1+c1, wherein c is the number of circles in the first zone arcs, and wherein n1=30, and c1=10 or greater; an electronics housing connected to the slider; an electronics controller within the slider housing; a motion sensor operationally connected to the electronics controller and configured to sense an extent of longitudinal movement along the device, wherein the longitudinal movement is proportional to a size of the clinical lesion being measured, and one or more of: a slider display on the slider housing that is operationally connected to the electronics controller, wherein the electronics controller, responsive to the sensing, is configured to control the slider display to provide display indicia indicative of the one or more of radius R, area A and volume V, radius doubling number, area doubling number and volume doubling number of the clinical lesion being measured; and a remote display, in wireless communication with the electronics controller, wherein the electronics controller, responsive to the sensing, is configured to control the remote display to provide display indicia indicative of the one or more of radius R, area A and volume V, radius doubling number, area doubling number and volume doubling number of the clinical lesion being measured. ### Claim 6 (depends on 5) The device of claim 5, including: the slider display on the slider housing that is operationally connected to the electronics controller, wherein the electronics controller, responsive to the sensing, is configured to control the slider display to provide display indicia indicative of the one or more of radius R, area A and volume V, radius doubling number, area doubling number and volume doubling number of the clinical lesion being measured. ### Claim 7 (depends on 6) The device of claim 6, wherein: the data zones include: a second zone that is laterally adjacent the first zone, the second zone defining a second zone first end that is longitudinally aligned with the first zone, the second zone extending longitudinally aft from the second zone first end to a second zone second end, wherein: the second zone defines a graduated line gauge and defines second zone size markers, wherein the second zone size markers identify one or more of radius R, area A, volume V, and the SDN of the clinical lesion. ### Claim 8 (depends on 7) The device of claim 7, including: a third zone defining a third zone first end adjacent to the first zone second end, and the third zone extending longitudinally aft from the third zone first end to a third zone second end, wherein: the third zone defines third zone circles and includes third zone size markers, the third zone circles being distributed in a non-overlapping configuration and defining second mutually unique radiuses R2 ranging from a second minimum radius R2min of a third zone first circle to a second maximum radius R2max of a third zone last circle; each successively larger circle in the third zone circles is larger than each successively smaller circle in the third zone circles by the first multiplication factor; the first minimum radius R1min of the first zone arcs is the same as or greater than the second maximum radius R2max of the third zone circles; the third zone size markers identify one or more of radius R, area A, volume V and the size doubling number (SDN) of the clinical lesion having a size that corresponds to a respective one of the third zone circles. ### Claim 9 (depends on 8) The device of claim 8, wherein: wherein the third zone first circle represents 2{circumflex over ( )}n2 volume doublings of the single tumor cell relative to the clinical lesion, and the third zone last circle represents 2{circumflex over ( )}m2 volume doublings relative to the single tumor cell, where m2=n2+c2, wherein c2 is the number of circles in the third zone circles, and wherein n2=24, and c2=7 or more. ### Claim 10 (depends on 9) The device of claim 9, wherein: the device defines a ruler that is at least partially transparent, wherein the planar surface is approximately rectangular and is smaller in a lateral direction L1 than a longitudinal direction L2. ### Claim 11 (depends on 5) The device of claim 5, including: the remote display, in wireless communication with the electronics controller, wherein the electronics controller, responsive to the sensing, is configured to control the remote display to provide display indicia indicative of the one or more of radius R, area A and volume V, radius doubling number, area doubling number and volume doubling number of the clinical lesion being measured. ### Claim 12 (depends on 11) The device of claim 11, wherein: the data zones include: a second zone that is laterally adjacent the first zone, the second zone defining a second zone first end that is longitudinally aligned with the first zone, the second zone extending longitudinally aft from the second zone first end to a second zone second end, wherein: the second zone defines a graduated line gauge and defines second zone size markers, wherein the second zone size markers identify one or more of radius R, area A, volume V, and the SDN of the clinical lesion. ### Claim 13 (depends on 12) The device of claim 12, including: a third zone defining a third zone first end adjacent to the first zone second end, and the third zone extending longitudinally aft from the third zone first end to a third zone second end, wherein: the third zone defines third zone circles and includes third zone size markers, the third zone circles being distributed in a non-overlapping configuration and defining second mutually unique radiuses R2 ranging from a second minimum radius R2 min of a third zone first circle to a second maximum radius R2max of a third zone last circle; each successively larger circle in the third zone circles is larger than each successively smaller circle in the third zone circles by the first multiplication factor; the first minimum radius R1min of the first zone arcs is the same as or greater than the second maximum radius R2max of the third zone circles; the third zone size markers identify one or more of radius R, area A, volume V and the size doubling number (SDN) of the clinical lesion having a size that corresponds to a respective one of the third zone circles. ### Claim 14 (depends on 13) The device of claim 13, wherein: wherein the third zone first circle represents 2{circumflex over ( )}n2 volume doublings of the single tumor cell relative to the clinical lesion, and the third zone last circle represents 2 m2 volume doublings relative to the single tumor cell, where m2=n2+c2, wherein c2 is the number of circles in the third zone circles, and wherein n2=24, and c2=7 or more. ### Claim 15 (depends on 14) The device of claim 14, wherein: the device defines a ruler that is at least partially transparent, wherein the planar surface is approximately rectangular and is smaller in a lateral direction L1 than a longitudinal direction L2.