# US 11,906,606 B2 · NMR measurement unit fixable within a process channel > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,906,606 B2 - Document ID: US11906606B2 - Status: Granted - Kind: B2 - Application number: 17/770,358 - Filed: 2020-10-21 - Published: 2022-12-15 - Granted: 2024-02-20 - Earliest claimed: 2019-10-24 - Assignees: Kaakkois-Suomen Ammattikorkeakoulu Oy - Applicants: Kaakkois-Suomen Ammattikorkeakoulu Oy - Inventors: Yrjö Hiltunen; Ekaterina Nikolskaya - Web page: https://patentgrep.com/patent/US11906606B2 ## CPC - G01R 33/30: Sample handling arrangements, e.g. sample cells, spinning mechanisms - G01R 33/307: {specially adapted for moving the sample relative to the MR system, e.g. spinning mechanisms, flow cells or means for positioning the sample inside a spectrometer} - G01N 24/082: {Measurement of solid, liquid or gas content} - G01R 33/448: {Relaxometry, i.e. quantification of relaxation times or spin density (G01R33/50 takes precedence)} - G01F 1/716: using electron paramagnetic resonance [EPR] or nuclear magnetic resonance [NMR] - G01R: MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES (indicating correct tuning of resonant circuits H03J3/12) - G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q) - G01F: MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME ## Abstract The invention relates to an NMR system, and more particularly to an NMR measurement unit including a flow channel for separating a sample from a fluid stream in a process channel, a magnet arranged relative to flow channel for creating a magnetic field in part of flow channel, a coil arranged relative to flow channel for exciting NMR active nuclei of the sample in flow channel and for receiving the frequency pulse that returns to coil from NMR active nuclei, a frame comprising a fastening flange for sealing NMR measurement unit to process channel and a chamber that is closed relative to fluid stream and connected to fastening flange, arranged to be installed mainly inside process channel, within which chamber magnet and coil are arranged and through which chamber the flow channel passes, the frame installable such that flow channel is positioned inside process channel. ## Claims ### Claim 1 An NMR measurement unit comprising a flow channel comprising a first end and a second end for separating a sample from a fluid stream present in a process channel via the first end and for returning the sample to the fluid stream via the second end; a magnet arranged in connection with the flow channel for creating a magnetic field at least in part of the flow channel; a coil arranged in connection with the flow channel for exciting an NMR active nuclei of the sample moving in the flow channel and for receiving a frequency pulse that returns to the coil from the NMR active nuclei; a frame being installable in such a way that the flow channel is positioned inside the process channel, the frame comprising a fastening flange for sealing and fastening the NMR measurement unit to an inspection hatch or a service opening in a wall of the process channel, and the NMR measurement unit is adapted to be installed in the inspection hatch or the service opening, respectively, of the wall of the process channel by means of the fastening flange; a chamber connected to the fastening flange and arranged to be installed at least mainly inside the process channel, said chamber is closed at least relative to the fluid stream, and within said chamber the magnet and the coil are arranged, and through said chamber the flow channel passes, and wherein both the magnet and the coil encircle the flow channel. ### Claim 2 (depends on 1) The NMR measurement unit according to claim 1, further comprising a first valve and a second valve both arranged in the flow channel inside the chamber, the first valve preceding the magnet and the second valve following the magnet, for stopping the sample in a region of the magnetic field. ### Claim 3 (depends on 1) The NMR measurement unit according to claim 1, further comprising a first valve and a pump both arranged in the flow channel inside the chamber, the first valve preceding the magnet and the pump following the magnet or the pump preceding the magnet and the first valve following the magnet, for stopping the sample in the region of the magnetic field. ### Claim 4 (depends on 2) The NMR measurement unit according to claim 2, wherein said flow channel further comprising a pipe equipped with a coating that prevents soiling, having two ends. ### Claim 5 (depends on 3) The NMR measurement unit according to claim 3, wherein said flow channel further comprising a pipe equipped with a coating that prevents soiling, having two ends. ### Claim 6 (depends on 4) The NMR measurement unit according to claim 4, wherein the pipe comprising fastening equipment for fastening the pipe removably by one said end to the first valve and by another said end to the second valve or to a pump, instead of the second valve. ### Claim 7 (depends on 5) The NMR measurement unit according to claim 5, wherein the pipe comprising fastening equipment for fastening the pipe removably by one said end to the first valve and by another said end to the second valve or to a pump, instead of the second valve. ### Claim 8 (depends on 1) The NMR measurement unit according to claim 1, wherein the chamber extends from the fastening flange perpendicularly. ### Claim 9 (depends on 1) The NMR measurement unit according to claim 1, wherein, seen in a perpendicular direction relative to the fastening flange, the chamber has a round shape for reducing flow resistance caused by the NMR measurement unit. ### Claim 10 (depends on 1) The NMR measurement unit according to claim 1, wherein, seen in a perpendicular direction relative to the fastening flange, the chamber has an elliptical shape for reducing the flow resistance caused by the NMR measurement unit. ### Claim 11 (depends on 1) The NMR measurement unit according to claim 1, the chamber comprising a closable cover for closing the NMR measurement unit. ### Claim 12 (depends on 1) The NMR measurement unit according to claim 1, the fastening flange further comprising a bolt rim for fastening the NMR measurement unit to an opening included in the wall of the process channel. ### Claim 13 (depends on 12) The NMR measurement unit according to claim 12, the opening is the service opening or the inspection hatch. ### Claim 14 (depends on 1) The NMR measurement unit according to claim 1, the NMR measurement unit being a time domain NMR measurement unit. ### Claim 15 (depends on 1) The NMR measurement unit according to claim 1, wherein the NMR active nucleus is a proton. ### Claim 16 (depends on 1) The NMR measurement unit according to claim 1, wherein the fluid stream is a liquid stream. ### Claim 17 (depends on 1) The NMR measurement unit according to claim 1, wherein an inner diameter of the flow channel is 2-30 mm. ### Claim 18 (depends on 1) The NMR measurement unit according to claim 1, wherein an inner diameter of the flow channel is 10-20 mm. ### Claim 19 (depends on 1) An NMR measurement system, comprising: an NMR measurement unit according to claim 1 for performing an NMR measurement on a sample in a process channel for forming a measurement signal; and a computing unit operatively connected to the NMR measurement unit for controlling operation of the NMR measurement unit and computing selected properties based on the measurement signal. ### Claim 20 (depends on 19) The NMR measurement system according to claim 19, wherein said NMR measurement unit further comprising a communication cable for transferring control commands from the computing unit to the NMR measurement unit and for transferring measurement data from the NMR measurement unit to the computing unit, and a frame comprising a lead-through for leading through the communication cable.