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US 11,906,528 B2Granted
Kits and methods to distinguish false labor and true labor
AssigneesWayne State University, The United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsAdi L. Tarca, Piya Chaemsaithong, Tinnakorn Chaiworapongsa, Sonia S. Hassan, Roberto Romero
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Abstract
Kits and methods to distinguish between false and true labor are provided. The kits and methods can utilize differences in abundance and/or differences in the rate of change in abundance of B7-H2, SORC2, TF, C1-Esterase Inhibitor, Ran, IMDH1 and/or PGAM1, as markers of true labor.
Claims19
A method, comprising:
- obtaining a sample from a pregnant female experiencing symptoms associated with false labor and true labor;
- and
- measuring in the sample for abundance of:
- (i) tissue factor (TF), ICOS Ligand (B7-H2), VPS10 Domain Containing Receptor SorCS2 (SORC2), and Plasma Protease C1 Inhibitor (C1-Esterase Inhibitor);
- or
- (ii) TF, Ras-related Nuclear protein (Ran), Inosine-5′-monophosphate dehydrogenase (IMDH1), and Phosphoglycerate mutase 1 (PGAM1).
3 more elements
A method, comprising:
- obtaining a sample from a pregnant female experiencing symptoms associated with false labor and true labor;
- and
- measuring in the sample a level or an amount of each of:
- (i) tissue factor (TF), ICOS Ligand (B7-H2), VPS10 Domain Containing Receptor SorCS2 (SORC2), and Plasma Protease C1 Inhibitor (C1-Esterase Inhibitor);
- or
- (ii) TF, Ras-related Nuclear protein (Ran), Inosine-5′-monophosphate dehydrogenase (IMDH1), and Phosphoglycerate mutase 1 (PGAM1).
3 more elements
A method, comprising:
- obtaining a sample from a pregnant female experiencing symptoms associated with false labor and true labor;
- and
- measuring in the sample abundance of tissue factor (TF) in combination with
- (i) ICOS Ligand (B7-H2) and/or VPS10 Domain Containing Receptor SorCS2 (SORC2);
- or
- (ii) Ras-related Nuclear protein (Ran), Inosine-5′-monophosphate dehydrogenase (IMDH1), and/or Phosphoglycerate mutase 1 (PGAM1).
3 more elements
Dependencies are inferred from the claim text.