# US 11,906,425 B2 · Simulation sample design method, simulation sample manufacturing method, simulation sample design device, program, and recording medium > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,906,425 B2 - Document ID: US11906425B2 - Status: Granted - Kind: B2 - Application number: 17/615,896 - Filed: 2020-06-01 - Published: 2022-10-06 - Granted: 2024-02-20 - Earliest claimed: 2019-06-19 - Assignees: Hamamatsu Photonics K.K. - Applicants: Hamamatsu Photonics K.K. - Inventors: Kenji Yoshimoto; Yukio Ueda - Web page: https://patentgrep.com/patent/US11906425B2 ## CPC - G01N 21/359: using near infrared light - A61B 5/1455: using optical sensors, e.g. spectral photometrical oximeters - A61B 5/1495: Calibrating or testing of in-vivo probes - G01N 21/278: {Constitution of standards} - G01N 21/3563: for analysing solids; Preparation of samples therefor - G01N 33/442: {Resins; Plastics} - G01N 21/4785: {Standardising light scatter apparatus; Standards therefor} - G01N 2201/121: Correction signals - G01N 2201/129: Using chemometrical methods - G01N 2201/13: Standards, constitution - G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q) - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract A phantom design method includes a correction step and a calculation step. In the correction step, an absorption spectrum of a target of spectroscopic measurement by a near infrared spectrometer is corrected based on a refractive index of the target and a refractive index of a resin used as a base material of a phantom to generate a corrected absorption spectrum. In the calculation step, based on an absorption spectrum of the resin and an absorption spectrum of each of N types of dyes, a concentration of each of the N types of dyes to be contained in the base material is calculated such that an absorption spectrum of the phantom constituted by the base material containing the N types of dyes approximates the corrected absorption spectrum in a predetermined wavelength range of a near infrared region. ## Claims ### Claim 1 A phantom design method for designing a phantom used in evaluating performance of a near infrared spectrometer, the method comprising: performing a correction of correcting an absorption spectrum of a target of spectroscopic measurement by the near infrared spectrometer based on a refractive index of the target and a refractive index of a resin used as a base material of the phantom to generate a corrected absorption spectrum; and performing a calculation of calculating, based on an absorption spectrum of the resin and an absorption spectrum of each of N types of dyes, N being 2 or more, a concentration of each of the N types of dyes to be contained in the base material such that an absorption spectrum of the phantom constituted by the base material containing the N types of dyes approximates the corrected absorption spectrum in a predetermined wavelength range of a near infrared region. ### Claim 2 (depends on 1) The phantom design method according to claim 1, wherein, in the calculation, a coincidence degree between the absorption spectrum of the phantom constituted by the base material containing the N types of dyes with the calculated concentrations and the corrected absorption spectrum is obtained. ### Claim 3 (depends on 2) The phantom design method according to claim 2, wherein, in the calculation, for each group including any N types of dyes out of M types of dyes, M being 3 or more, the concentration of each of the N types of dyes to be contained in the base material is calculated and the coincidence degree is obtained, and the N types of dyes and the concentrations of any one group are selected based on the number of types of dyes and the coincidence degree of each group. ### Claim 4 (depends on 1) The phantom design method according to claim 1, wherein the predetermined wavelength range in the calculation includes a range of 750 nm to 850 nm. ### Claim 5 (depends on 1) A phantom preparation method comprising: calculating the concentration of each of the N types of dyes in the base material by the phantom design method according to claim 1; and preparing the phantom by causing the base material to contain the N types of dyes according to the calculated concentrations. ### Claim 6 (depends on 5) The phantom preparation method according to claim 5, wherein the phantom is prepared by causing the base material to contain scattering particles in addition to the N types of dyes. ### Claim 7 (depends on 1) A program for causing a computer to execute the correction step and the calculation step of the phantom design method according to claim 1. ### Claim 8 (depends on 7) A computer readable recording medium recording the program according to claim 7. ### Claim 9 A phantom design apparatus for designing a phantom used in evaluating performance of a near infrared spectrometer, the apparatus comprising: a processor configured to perform a correction of correcting an absorption spectrum of a target of spectroscopic measurement by the near infrared spectrometer based on a refractive index of the target and a refractive index of a resin used as a base material of the phantom to generate a corrected absorption spectrum; and perform a calculation of calculating, based on an absorption spectrum of the resin and an absorption spectrum of each of N types of dyes, N being 2 or more, a concentration of each of the N types of dyes to be contained in the base material such that an absorption spectrum of the phantom constituted by the base material containing the N types of dyes approximates the corrected absorption spectrum in a predetermined wavelength range of a near infrared region. ### Claim 10 (depends on 9) The phantom design apparatus according to claim 9, wherein, in the calculation, the processor is configured to obtain a coincidence degree between the absorption spectrum of the phantom constituted by the base material containing the N types of dyes with the calculated concentrations and the corrected absorption spectrum. ### Claim 11 (depends on 10) The phantom design apparatus according to claim 10, wherein, in the calculation, the processor is configured to calculate, for each group including any N types of dyes out of M types of dyes, M being 3 or more, the concentration of each of the N types of dyes to be contained in the base material and obtain the coincidence degree, and select the N types of dyes and the concentrations of any one group based on the number of types of dyes and the coincidence degree of each group. ### Claim 12 (depends on 9) The phantom design apparatus according to claim 9, wherein the predetermined wavelength range in the calculation includes a range of 750 nm to 850 nm. ### Claim 13 (depends on 9) The phantom design apparatus according to claim 9, further comprising: a storage configured to store a program that causes the processor to execute the correction and the calculation.