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US 11,905,530 B2Granted
Cell encapsulation device comprising a pancreatic progenitor cell population
AssigneeViaCyte, Inc.
InventorsAlan D. Agulnick, Olivia Kelly, Yuki Ohi, Allan Robins, Thomas Schulz
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Abstract
Disclosed herein are cell culture compositions, for example, pancreatic cell culture compositions, derived from dedifferentiated human reprogrammed pluripotent stem cells, such as induced pluripotent stem (iPS) cells, and methods for producing and using such cell culture compositions.
Claims15
A device comprising,
- a semi-permeable membrane encapsulating an in vitro mammalian pancreatic progenitor cell population in a medium,
- wherein the mammalian pancreatic progenitor cell population comprises an endocrine cell subpopulation and a non-endocrine cell subpopulation, wherein at least 30% of the pancreatic cell population is the non-endocrine cell subpopulation, and
- wherein the medium is capable of supporting differentiation of the mammalian pancreatic progenitor cell population and comprises L-alanyl-L-glutamine.
Dependencies are inferred from the claim text.