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US 11,905,250 B2Granted
Methods for preparation of jasmonate compounds
AssigneeVidac Pharma Ltd.
InventorsPaul Salama, Oren Menahem Becker
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Abstract
This invention relates to methods for preparation of jasmonate compounds via a salt of jasmonic acid.
Claims21
A method of preparing a compound of formula (I)
- wherein R is a heteroaryl group,
- the method comprising
- (a) treating jasmonic acid salt (9)
- with an acid at a temperature of from about 0° C. to about 15° C. to provide Compound (8),
- and
- (b) reacting Compound (8) with a hydroxylheteroaryl to provide the compound of formula (I).
3 more elements
A method of preparing jasmonic acid salt (9)
- the method comprising
- (a) hydrolyzing Compound (6)
- with a base at a temperature of from about 20° C. to about 30° C. to form a crude Compound (8)
- and
- (b) reacting the crude compound (8) with dicyclohexylamine at a temperature of from about 0° C. to about 10° C. in an organic solvent to provide jasmonic acid salt (9).
2 more elements
Dependencies are inferred from the claim text.