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AssigneeThe Chinese University of Hong Kong
InventorsYing-Yeung Yeung, Xiaodong Xiong, Tianyu Zheng, Xinyan Wang, Ying-Lung Steve Tse
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The subject invention pertains to a method of halogenating phenols, yielding a range of halogenated phenols with enantiomeric ratio of up to 99.5:0.5. In certain embodiments, the subject invention pertains to a method of asymmetric halogenation of bisphenol, yielding a range of chiral bisphenol ligands. The novel chiral bisphenols are potent privileged catalyst cores that can be applied to the preparation of ligands for various catalytic asymmetric reactions. The catalyst library can easily be accessed because late-stage modification of the scaffold can readily be executed through cross-coupling of the halogen handles on the bisphenols.
A method of halogenation, the method comprising contacting a reactant bisphenol with a source of a halogen in the presence of a catalyst under process conditions sufficient to prepare a halogenated bisphenol, wherein
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