Dynamic combinatorial library based on pseudopeptides and its use for the detection of cysteine and other biothiols
AssigneeConsejo Superior De Investigaciones Cientificas (Csic)
InventorsIgancio Alfonso Rodriguez, Jordi Sola Oller, Maria Lafuente Fabra
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Abstract
The present invention relates to a dynamic chemical network that mimics the transfer of information and ultimately produces a chemical response, for example a readable signal. More specifically, the invention discloses a dynamic system able to selectively sense a biologically-relevant analyte, such as cysteine, in its reduced or its oxidized form (cystine) in aqueous media and in a biofluid (such as urine) for diagnostic application. Due to this property, said dynamic system is useful for the detection of cysteine or its derivatives in biological fluids such as urine.
Claims16
A mixture of molecules comprising at least a compound as defined by formula (I):
- or an isomer or a salt thereof, wherein:
- Ra and Rb are independently selected from H, —CONRR′, —COOR, —NRR′, —OH, —C(NH)NH2, —CH(OH)CH3, aryl-(C6-C10) or heteroaryl-(C6-C10);
- R and R′ are independently selected from H or alkyl-(C1-C5);
- m is an integer selected from 0, 1, 2, 3 or 4;
- n is an integer selected from 1 or 2;
- at least a compound of formula (II):
- or an isomer or a salt thereof, wherein:
- n′ is an integer selected from 1 or 2;
- and at least a compound of formula (III):
- or an isomer or a salt thereof, wherein:
- Rc represents an aromatic chromophore;
- Y is selected from NHCO or CONH;
- Z is selected from H, —NH2, —OH or —COOH;
- p is an integer selected from 0, 1, 2 or 3.
Dependencies are inferred from the claim text.