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US 11,905,230 B2Granted
Phenoxyacetic acid derivatives, preparation method thereof and use thereof as medicament
AssigneeChina Pharmaceutical University
InventorsHai Qian, Wenlong Huang, Chunxia Liu, Jianyong Yang
Life of this patent
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Abstract
The present invention relates to a novel phenoxyacetic acid derivative represented by the general formula (I), preparation method thereof and use of a pharmaceutical composition containing the derivative in preparing a medicament for treating diabetes and metabolic syndrome. The phenoxyacetic acid derivatives have excellent in vivo hypoglycemic activity, which can be used for preventing or treating diabetes.
Claims2
A compound is selected from the group consisting of
- 2-(4-((2′-chloro-[1,1′-biphenyl]-3-methylene)amino)-2-fluorophenoxy)acetic acid (I-2),
- 2-(4-((2′-methoxy-[1,1′-biphenyl]-3-methylene)amino)-2-fluorophenoxy)acetic acid (I-6),
- 2-(4-((2′-nitrile-[1,1′-biphenyl]-3-methylene)amino)-2-fluorophenoxy)acetic acid (I-7),
- 2-(4-((2′-trifluoromethyl-[1,1′-biphenyl]-3-methylene)amino)-2-fluorophenoxy)acetic acid (I-8),
- 2-(4-(([1,1′-biphenyl]-3-methylene)amino)-2-fluorophenoxy)acetic acid (I-11),
- 2-(4-((2′-chloro-[1,1′-biphenyl]-3-methylene)amino)phenoxy)acetic acid (I-24),
- 2-(4-((2′-trifluoromethyl-[1,1′-biphenyl]-3-methylene)amino)phenoxy)acetic acid (I-28),
- 2-(4-((4′-trifluoromethoxy-2′,6′-dimethyl-[1,1′-biphenyl]-3-methylene)amino)phenoxy)acetic acid (I-29),
- 2-(4-(((4′-ethoxy-2′-methyl-[1,1′-biphenyl]-3-yl)methylene)amino)phenoxy)acetic acid (I-31),
- 2-(4-((2′-trifluoromethoxy-[1,1′-biphenyl]-3-methylene)amino)phenoxy)acetic acid (I-32),
- 2-(4-((2′-trifluoromethoxy-[1,1′-biphenyl]-3-methylene)amino-2-fluoro)phenoxy)acetic acid (I-33),
- 2-(4-((4′-trifluoromethoxy-2′,6′-dimethyl-[1,1′-biphenyl]-3-methylene)amino)-2-fluorophenoxy)acetic acid (I-34),
- 2(4-(((4′-(hexyloxy)-2′,6′-dimethyl-[1,1′-biphenyl]-3-yl)methyl)amino)phenoxy)acetic acid (I-43), and
- 2(4-(((4′-(cyclohexyloxy)-2′,6′-dimethyl-[1,1′-biphenyl]-3-yl)methyl)amino)phenoxy)acetic acid (I-45).
11 more elements
Dependencies are inferred from the claim text.