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US 11,904,024 B2Granted
Eye drop composition
AssigneeAratana Therapeutics, Inc.
InventorsNesya Goris, Johan Neyts, Erwin Blomsma, Stefaan Wera, Ainola Billiet, Joeri Auwerx, Veerle Debeurme, Maryline Roe, Pascal Puig
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Abstract
The present invention relates to an eye-drop composition comprising 2-amino-9-[[(1S,2R)-1,2-bis(hydroxymethyl)cyclopropyl]methyl]-1,9-dihydro-6H-Purin-6-one, and the use thereof for the diagnosis and treatment of herpetic eye infections in companion animals.
Claims15
A composition comprising:
- at least 0.1% w/v 2-amino-9-[[(1S,2R)-1,2-bis(hydroxymethyl)cyclopropyl]methyl]-1,9-dihydro-6H-Purin-6-one;
- and
- at least 10% w/v of a cyclodextrin.
A method for preparing an ophthalmic solution, comprising the steps of:
- a) providing a solution comprising at least 10% w/v of a cyclodextrin;
- b) adding 2-amino-9-[[(1S,2R)-1,2-bis(hydroxymethyl)cyclopropyl]methyl]-1,9-dihydro-6H-Purin-6-one to said solution;
- c) solubilizing the 2-amino-9-[[(1S,2R)-1,2-bis(hydroxymethyl)cyclopropyl]methyl]-1,9-dihydro-6H-Purin-6-one added in step b);
- d) repeating steps b) and c) until a concentration of 2-amino-9-[[(1S,2R)-1,2-bis(hydroxymethyl)cyclopropyl]methyl]-1,9-dihydro-6H-Purin-6-one in said solution of at least 1 mg/mL is obtained;
- e) optionally, adding at least 0.008 mg/mL thiomersal.
2 more elements
Dependencies are inferred from the claim text.