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US 11,903,954 B2Granted
Method of treating urolithiasis
AssigneeApplaud Medical, Inc.
InventorsDaniel J. Laser, Alice Luong, Robert G. Miotke
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Abstract
The present disclosure provides phospholipid-containing compounds, pharmaceutical compositions and microspheres that exhibit high affinity for mineralized metals. The present disclosure also provides strategies for using said compounds, compositions and microspheres in the treatment of nephrolithiasis or kidney stone disease, and methods of manufacturing and preparing said compounds and compositions.
Claims16
A method of treating an abnormal or obstructive mass, the method comprising:
- administering to a subject with the abnormal or obstructive mass an effective amount of a microsphere composition comprising microspheres containing fluid, so as to bring the microspheres into contact with the abnormal or obstructive mass within the subject, and
- directionally applying an energy to the abnormal or obstructive mass at a frequency that excites the fluid within the microspheres;
- wherein the microsphere composition comprises:
- a compound of Formula I
- or a salt, isomer, or salt of an isomer thereof;
- wherein:
- n is from 10 to 30;
- m is from 1 to 100;
- and
- X is selected from the group consisting of:
- hydrogen, silyl, acyl, aminoacyl, thioacyl, aminocarbonyl, aminoacyl carbonyloxy, aminothiocarbonyl, aminosulfonyl, amidino, substituted sulfonyl, substituted sulfinyl, carboxy ester, phthalimido, OH, SO3H and PO3H;
- and
- a pharmaceutically acceptable excipient, wherein the abnormal or obstructive mass is a urinary stone or a kidney stone.
10 more elements
Dependencies are inferred from the claim text.