Multi-analyte sensing tissue-integrating sensors

A sensor, comprising:

• a first polymer-luminescent compound including a first polymer and a fluorescent dye configured to emit light in an emission spectrum in response to being excited with light having an excitation frequency, the first polymer-luminescent compound configured to produce a first luminescent signal in the presence of a first analyte;
• and
• a second polymer-luminescent compound including a second polymer and the fluorescent dye, the second polymer-luminescent sensing compound configured to produce a second luminescent signal in the presence of a second analyte, a spectrum of the second luminescent signal overlapping a spectrum of the first luminescent signal, the second luminescent signal having a longer luminescent lifetime than the first luminescent signal.

A sensor, comprising:

• a first polymer-luminescent compound configured to produce a first luminescent signal in the presence of a first analyte, the first polymer-luminescent compound including a first polymer and a fluorescent dye configured to emit light in an emission spectrum in response to being excited with light having an excitation frequency;
• and
• a second polymer-luminescent sensing compound configured to produce a second luminescent signal in the presence of a second analyte that has a spectrum that overlaps a spectrum of the first luminescent signal, the second polymer-luminescent compound including a second polymer and the fluorescent dye, at least one of the first polymer or the second polymer configured to alter temporal characteristics of the fluorescent dye such that the second luminescent signal has a longer lifetime than the first luminescent signal.

A sensor, comprising:

• a first polymer-luminescent sensing compound configured to produce a first luminescent signal in the presence of a first analyte;
• and
• a second polymer-luminescent sensing compound configured to produce a second luminescent signal in the presence of a second analyte, the first luminescent signal and the second luminescent signal having a common spectral signature, the second luminescent signal having a longer luminescent lifetime than the first luminescent signal.

A sensor, comprising:

• a first polymer-luminescent sensing compound including an oxygen-sensitive dye and configured to produce a first luminescent signal in the presence of oxygen;
• a second polymer-luminescent sensing compound including the oxygen-sensitive dye and configured to produce a second luminescent signal in the presence of an analyte selected from the group consisting of glucose, lactate, alcohol, ascorbate, histamine, cholesterol, and pyruvate, a spectrum of the second luminescent signal overlapping a spectrum of the first luminescent signal, the second luminescent signal having a longer luminescent lifetime than the first luminescent signal.

A method,

• formulating a first polymer-luminescent sensing compound by polymerizing a fluorescent dye with at least one of a first monomer, a first crosslinker, or a first polymer such that when illuminated by an excitation signal, the first polymer-luminescent sensing compound produces a first luminescent signal in the presence of a first analyte;
• and
• formulating a second polymer-luminescent sensing compound by polymerizing the fluorescent dye with at least one of a second monomer, a second crosslinker, or a second polymer such that when illuminated by the excitation signal, the second polymer-luminescent sensing compound produces a second luminescent signal in the presence of a second analyte, the second luminescent signal having a longer luminescent lifetime than the first luminescent signal.