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US 11,903,695 B2Granted
Sensor devices and systems for monitoring markers in breath
AssigneeBiolum Sciences LLC
InventorsEdward C. Allegra, Miguel E. Quimbar, Jack P. Reynolds
Life of this patent
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Abstract
The disclosure relates to devices, systems and methods for detecting markers in breath, more specifically volatile and non-volatile markers associated with pulmonary diseases such as, for example, asthma, chronic obstructive pulmonary disease (COPD), or cystic fibrosis (CF), in exhaled breath condensate (EBC).
Claims53
An article for measuring a disease marker in exhaled breath condensate (EBC) comprising,
- (a) a vehicle chamber containing a vehicle for a probe;
- (b) an auxiliary chamber that is physically separated from the vehicle chamber via a first separator, wherein the auxiliary chamber contains the probe that is specific to the marker;
- (c) a reaction chamber that is physically separated from the vehicle chamber or the auxiliary chamber or both the reaction chamber and the auxiliary chamber via a second separator, wherein the reaction chamber contains an surface for detection of the interaction between the probe and the marker;
- and
- (d) a detector for detecting a signal issued from said reaction chamber.
2 more elements
A system for measuring a disease marker in exhaled breath condensate (EBC) comprising,
- (I) an article comprising,
- (a) a vehicle chamber containing a vehicle for a probe for the detection of the marker;
- (b) an auxiliary chamber that is physically separated from the vehicle chamber via a first separator, wherein the auxiliary chamber contains the probe that is specific to the marker;
- and
- (c) a reaction chamber that is physically separated from the vehicle chamber or the auxiliary chamber or both the reaction chamber and the auxiliary chamber via a second separator, wherein the reaction chamber contains an surface for detection of the interaction between the probe and the marker;
- (II) a collection unit comprising a first end that is attachable to the article and a second end that contains a breathing inlet;
- and;
- (III) a receptacle for analytically measuring a signal generated by the probe-marker interaction.
5 more elements
Dependencies are inferred from the claim text.