Using genetic and phenotypic data sets for drug discovery clinical trials

A system comprising one or more computers and one or more storage devices storing instructions that, when executed by the one or more computers, cause the one or more computers to perform operations comprising:

• for each user of a first plurality of users:
• generating a health profile for the user based on (i) genetic data of the user and (ii) health data of the user resulting from monitoring over a time period, the health data of the user being received from one or more health monitoring devices of the user over a time period;
• determining, based on the health profile of the user, a particular health risk for the user;
• determining, for the particular health risk, a first monitoring profile for the user that causes the one or more health monitoring devices to monitor the user to obtain one or more first types of health data according to the first monitoring profile, wherein the first monitoring profile includes first instructions that cause at least one of the one or more health monitoring devices to collect the one or more first types of health data;
• providing the first monitoring profile to the one or more health monitoring devices of the user;
• receiving, from the one or more health monitoring devices of the user, epigenetic data including measures of one or more epigenetic factors for the user;
• determining whether a health change event for the particular health risk has occurred for the user based, at least in part, on the genetic data of the user and the epigenetic data of the user, wherein the health change event is a change of the particular health risk of the user from a first level to a second level;
• for each user of a second plurality of users for which the health change event has been determined to have occurred, wherein the second plurality of users is a subset of the first plurality of users:
• determining, for the particular health risk determined for the user, a second monitoring profile for the user that causes the one or more health monitoring devices of the user to monitor the user to obtain one or more second types of health data according to the second monitoring profile, wherein the second monitoring profile is different from the first monitoring profile and includes second instructions that cause at least one of the one or more health monitoring devices of the user to collect the one or more second types of health data, wherein:
• the second instructions are executable instructions that are configured to be executed by the one or more health monitoring devices of the user to automatically initiate monitoring of the user to obtain the one or more second types of health data, and that, upon execution of the second instructions by the one or more health monitoring devices of the user, direct the one or more health monitoring devices of the user to change an amount of monitoring performed by the one or more health monitoring devices according to the change in the particular health risk for the user;
• and
• providing, to the one or more health monitoring devices of the user, the second monitoring profile to cause the one or more health monitoring devices of the user to monitor the user to obtain the one or more second types of health data, wherein the one or more second types of health data are different from the one or more first types of health data.

One or more non-transitory computer storage media storing instructions that, when executed by one or more computers, cause the one or more computers to perform operations comprising:

• for each user of a first plurality of users:
• generating a health profile for the user based on (i) genetic data of the user and (ii) health data of the user resulting from monitoring over a time period, the health data of the user being received from one or more health monitoring devices of the user over a time period;
• determining, based on the health profile of the user, a particular health risk for the user;
• determining, for the particular health risk, a first monitoring profile for the user that causes the one or more health monitoring devices to monitor the user to obtain one or more first types of health data according to the first monitoring profile, wherein the first monitoring profile includes first instructions that cause at least one of the one or more health monitoring devices to collect the one or more first types of health data;
• providing the first monitoring profile to the one or more health monitoring devices of the user;
• receiving, from the one or more health monitoring devices of the user, epigenetic data including measures of one or more epigenetic factors for the user;
• determining whether a health change event for the particular health risk has occurred for the user based, at least in part, on the genetic data of the user and the epigenetic data of the user, wherein the health change event is a change of the particular health risk of the user from a first level to a second level;
• for each user of a second plurality of users for which the health change event has been determined to have occurred, wherein the second plurality of users is a subset of the first plurality of users:
• determining, for the particular health risk determined for the user, a second monitoring profile for the user that causes the one or more health monitoring devices of the user to monitor the user to obtain one or more second types of health data according to the second monitoring profile, wherein the second monitoring profile is different from the first monitoring profile and includes second instructions that cause at least one of the one or more health monitoring devices of the user to collect the one or more second types of health data, wherein:
• the second instructions are executable instructions that are configured to be executed by the one or more health monitoring devices of the user to automatically initiate monitoring of the user to obtain the one or more second types of health data, and that, upon execution of the second instructions by the one or more health monitoring devices of the user, direct the one or more health monitoring devices of the user to change an amount of monitoring performed by the one or more health monitoring devices according to the change in the particular health risk for the user;
• and
• providing, to the one or more health monitoring devices of the user, the second monitoring profile to cause the one or more health monitoring devices of the user to monitor the user to obtain the one or more second types of health data, wherein the one or more second types of health data are different from the one or more first types of health data.