Apparatus, systems, and methods for rapid cancer detection
Assignee4D Path Inc.
InventorsSatabhisa Mukhopadhyay, Tathagata Dasgupta
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Abstract
Presented herein are systems, methods, and apparatus that analyze molecular imprints for detecting cancerous cells. Embodiments of the present disclosure include systems, methods, and apparatus that analyze metabolic imprints of cells for cancer detection. In certain embodiments, the methods/systems comprise extracting thermal and thermodynamic quantities and properties from the molecular imprints. The thermal/thermodynamic quantities and/or further-processed quantities can be mapped on a universal cancer diagnostic scale for disease stratification, thereby providing/determining a normality status of the subject cells.
Claims21
A method comprising:
- receiving, by a processor, data representing at least one cell that has been identified in an area of an image and segmented into a nuclear area and a cellular area;
- calculating, by the processor for the at least one cell and based at least in part on the data, a plurality of information surface values each derived as a function of both:
- (i) a nuclear contrast feature, wherein the nuclear contrast feature comprises a temperature difference between the nuclear area and the cellular area;
- and
- (ii) a nuclear area feature, wherein the nuclear area feature comprises a ratio of the nuclear area to a nuclear volume projection;
- calculating, by the processor, a diagnostic score based at least in part on the plurality of information surface values;
- and
- determining, by the processor based at least in part on the diagnostic score, a normality status of the area of the image.
A system comprising:
- a processor;
- a memory having instructions stored thereon, wherein the instructions, when executed by the processor, cause the processor to perform operations comprising:
- receiving, by a processor, data representing at least one cell that has been identified in an area of an image and segmented into a nuclear area and a cellular area;
- calculating, by the processor for the at least one cell and based at least in part on the data, a plurality of information surface values each derived as a function of both:
- (i) a nuclear contrast feature, wherein the nuclear contrast feature comprises a temperature difference between the nuclear area and the cellular area;
- and
- (ii) a nuclear area feature, wherein the nuclear area feature comprises a ratio of the nuclear area to a nuclear volume projection;
- calculating, by the processor, a diagnostic score based at least in part on the plurality of information surface values;
- and
- determining, by the processor based at least in part on the diagnostic score, a normality status of the area of the image.
Dependencies are inferred from the claim text.