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US 11,901,060 B2Granted
Closed loop control of physiological glucose
AssigneeYpsomed AG
InventorsYamei Chen, Haoda Fu, Parag Garhyan, Ahmad Mohamad Haidar, Richard Earl Jones, Jr., Christopher Kovalchick, Marie Kearney Schiller, Monica Rixman Swinney, Howard Allan Wolpert
Life of this patent
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Abstract
The present disclosure relates to systems and methods for controlling physiological glucose concentrations in a patient.
Claims28
A system to control glucose in a patient, the system comprising:
- a medication delivery device configured to deliver insulin to the patient;
- and
- a controller in communication with the medication delivery device and including control logic operative to:
- execute a model predictive controller algorithm to determine a first medication dose of a first type of insulin having a first pharmacokinetic profile, the model predictive controller algorithm includes a plurality of model parameters having a first set of values that are predetermined and associated with the first type of insulin,
- determine a change from the first type of insulin to a second type of insulin having a second pharmacokinetic profile, in response to determining a change in a glycemic pattern or detecting a user notification, and
- execute the model predictive controller algorithm including the plurality of model parameters having a second set of values that are predetermined and associated with the second type of insulin, in response to the determined change to the second type of insulin, to determine a second medication dose of the second type of insulin, wherein the first pharmacokinetic profile is different than the second pharmacokinetic profile,
- wherein the medication delivery device is controlled by the controller to deliver insulin to the patient, according to the determined first medication dose and the determined second medication dose.
4 more elements
A system to control glucose in a patient, the system comprising:
- a medication delivery device configured to deliver insulin to the patient;
- and
- a controller in communication with the medication delivery device and including control logic operative to:
- execute a model predictive controller algorithm to determine a first medication dose of a first type of insulin having a first pharmacokinetic profile, the model predictive controller algorithm includes a plurality of model parameters having a first set of values that are predetermined and associated with the first type of insulin,
- determine a change from the first type of insulin to a second type of insulin having a second pharmacokinetic profile, in response to determining a change in a glycemic pattern or detecting a user notification, and
- execute the model predictive controller algorithm including the plurality of model parameters having a second set of values that are predetermined and associated with the second type of insulin, in response to the determined change to the second type of insulin, to determine a second medication dose of the second type of insulin, wherein the first pharmacokinetic profile is different than the second pharmacokinetic profile,
- wherein the control logic is further operative to determine the type of insulin in response to a comparison between a current area under a glucose curve (AUC) and a known AUC during a first hour after insulin delivery by the medication delivery device, and
- wherein the medication delivery device is controlled by the controller to deliver the determined type of insulin to the patient.
5 more elements
Dependencies are inferred from the claim text.