Systems and methods for whole-brain circuit-based neurostimulation to treat brain disorders

A non-transitory computer-accessible medium having stored thereon computer-executable instructions for determining one or more target regions for transcranial magnetic stimulation (TMS) treatment of a patient, wherein the computer-executable instructions are configured when executed by one or more processors to perform a method, comprising:

• receiving functional magnetic resonance imaging (fMRI) data of a head of the patient;
• analyzing functional connections of the patient's brain through analysis of the fMRI data by determining changes in any combination of a first fluctuation in amplitude of the fMRI imaging data, a second fluctuation in frequency of the fMRI data, or a third fluctuation in frequency relative to amplitude of the fMRI data;
• selecting a first plurality of brain regions having a change in activation, correlation, covariation, or a combination thereof with a larger number of brain networks or regions that is lower than that of other brain regions;
• selecting a second plurality of brain regions having a change in activation, correlation, covariation, or a combination thereof with a larger number of brain networks or regions that is higher than that of other brain regions;
• determining one or more target regions for TMS treatment of the patient based on the determination of changes in any combination of the first fluctuation, the second fluctuation, or the third fluctuation by comparing the first plurality of brain regions and the second plurality of brain regions with corresponding brain regions from a healthy control group matching an age range and gender of the patient, and selecting a potential target group of brain regions above a first threshold value and below a second threshold value;
• and
• causing TMS treatment to be administered to the patient at the one or more target regions selected from the potential target group of brain regions.