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US 11,899,015 B1Granted
Chimeric recombinant proteins and recombinant protein panels for the diagnosis of Lyme disease in animals and humans
AssigneeVirginia Commonwealth University
InventorRichard Marconi
Life of this patent
Estimating the term…
Abstract
Chimeric recombinant proteins for the detection of infection by Borreliella and/or diagnosis of Lyme disease are provided. Methods and devices for conducting immunoassays with the chimeric recombinant proteins are also provided.
Claims3
A recombinant chimeric polypeptide comprising, in order from amino to carboxy terminus:
- i) DbpB without N terminal A (SEQ ID NO:
- 76) or a variant thereof having at least 95% identity to SEQ ID NO:
- 76,
- BBA73 (SEQ ID NO:
- 3) or a variant thereof having at least 95% identity to SEQ ID NO:
- 73,
- BBK53 (SEQ ID NO:
- 4) or a variant thereof having at least 95% identity to SEQ ID NO:
- 4, and
- BBO238 (SEQ ID NO:
- 5) or a variant thereof having at least 95% identity to SEQ ID NO:
- 5;
- or
- ii) DbpB without N terminal A (SEQ ID NO:
- 76) or a variant thereof having at least 95% identity to SEQ ID NO:76,
- BBA73 (SEQ ID NO:
- 3) or a variant thereof having at least 95% identity to SEQ ID NO:
- 3, and
- BBK53 (SEQ ID NO:
- 4) or a variant thereof having at least 95% identity to SEQ ID NO:4;
- or
- iii) BBA24 (SEQ ID NO:
- 13) or a variant thereof having at least 95% identity to SEQ ID NO:13,
- DbpB (SEQ ID NO:
- 2) or a variant thereof having at least 95% identity to SEQ ID NO:
- 2,
- BBK19 (SEQ ID NO:
- 15) or a variant thereof having at least 95% identity to SEQ ID NO:
- 15, and
- VlsE (SEQ ID NO:
- 16) or a variant thereof having at least 95% identity to SEQ ID NO:16.
28 more elements
Dependencies are inferred from the claim text.