Method of detecting or quantifying detection target in specimen, composite particle, and reagent
AssigneeCanon Medical Systems Corporation
InventorsSatoru Sugita, Hirotoshi Tahara
Life of this patent
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Abstract
According to one embodiment, a method of detecting or quantifying a detection target in a specimen includes: irradiating a reaction mixture containing composite particles and the specimen with light to promote binding between the composite particles and the detection target; and performing measurement on the reaction mixture irradiated with the light to detect or quantify the detection target. The composite particles each include a carrier particle including two or more regions having different physical properties on a surface, and an affinity substance carried on the carrier particle and having affinity to the detection target. The light can be absorbed by at least one of the two or more regions.
Claims8
A method of detecting or quantifying a detection target in a specimen, the method comprising:
- irradiating a reaction mixture with infrared pulse laser light, the reaction mixture containing:
- (1) composite particles, each comprising a carrier particle including two regions including a first region made of a metal and a second region made of a nonmetal on a surface, and an affinity substance carried on the carrier particle and having affinity to the detection target, and (2) the specimen, the infrared pulse laser light being capable of being absorbed by the first region, to promote binding between the composite particles and the detection target;
- and
- irradiating the reaction mixture with a measurement light after the irradiation with the infrared pulse laser light, and measuring a transmitted light intensity or a scattered light intensity to detect or quantify the detection target based on a result of the measurement, wherein the irradiation with the infrared pulse laser light is stopped during the irradiation with the measurement light.
Dependencies are inferred from the claim text.