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US 11,899,012 B2Granted
Single-chain polymer-based target receptors for use in electrochemical detection of target analytes
AssigneeUniversity of New Hampshire
InventorsEdward Song, William Rudolf Seitz, Jeffrey M. Halpern
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Abstract
The present disclosure provides new approaches in developing templated polymer-based chemical receptors. At least some embodiments of the invention use a stimuli-responsive polymer [e.g., poly-Nisopropylacrylamide (pNIPAM)] as a polymer backbone with the incorporation of functional monomers (for analyte recognition). In at least some embodiments of the invention, vinylferrocene may be used as a redox-active label for electrochemical transduction.
Claims19
A method of generating an electrochemical sensor, comprising:
- obtaining a single-chain polymer comprising a carboxylic acid monomer, a monomer comprising a derivative of pyridine with a vinyl group, an organometallic compound, a monomer comprising a reversible addition-fragmentation chain transfer (RAFT) agent, and a backbone compound;
- generating a modified single-chain polymer by changing the RAFT agent to a thiol;
- and
- covalently linking the thiol to a sensor surface.
1 more element
Dependencies are inferred from the claim text.