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US 11,899,010 B2Granted
Modular point-of-care devices, systems, and uses thereof
AssigneeLabrador Diagnostics LLC
InventorsTammy Burd, Ian Gibbons, Elizabeth A. Holmes, Gary Frenzel, Anthony Joseph Nugent
Life of this patent
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Abstract
The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.
Claims20
A system for performing an assay capable of detecting an analyte in a biological sample, the system comprising:
- a cartridge comprising:
- a plurality of reagent units, wherein one or more of the plurality of reagent units are configured to store cartridge reagents, and
- a sample vessel configured to receive the biological sample;
- an assay assembly comprising:
- an addressable assay unit configured to receive the biological sample and to receive a first cartridge reagent from a first reagent unit of the plurality of reagent units of the cartridge,
- a reaction site arranged on an interior surface of the addressable assay unit, wherein the reaction site comprises an immobilized binding reagent configured to bind with the analyte, and
- an assembly tip in fluid communication with the addressable assay unit and comprising an opening, wherein the assembly tip is configured to place the addressable assay unit in fluid communication with the first reagent unit or the sample vessel of the cartridge;
- and
- a reader assembly configured to receive the cartridge and the assay assembly, wherein the reader assembly comprises:
- an automated fluid transfer device configured to move the assay assembly relative to the cartridge to selectively place the assembly tip of the assay assembly into the sample vessel or into the first reagent unit of the plurality of reagent units and to sequentially transfer the biological sample and the first cartridge reagent into the addressable assay unit via the assembly tip such that a reaction occurs that yields a signal indicative of a presence of the analyte, and
- a detection assembly configured to detect the signal indicative of the presence of the analyte.
8 more elements
A system for performing an assay capable of detecting an analyte in a biological sample, the system comprising:
- a cartridge comprising:
- a plurality of reagent units, wherein one or more of the plurality of reagent units are configured to store cartridge reagents,
- a sample vessel configured to receive the biological sample, wherein the plurality of reagent units and the sample vessel are arranged in a linear array, and
- an identifier configured to encode information corresponding to the contents of the cartridge;
- an assay assembly comprising:
- an addressable assay unit configured to receive the biological sample and to receive a first cartridge reagent from a first reagent unit of the plurality of reagent units of the cartridge,
- a reaction site arranged on an interior surface of the addressable assay unit, wherein the reaction site comprises an immobilized binding reagent configured to bind with the analyte, and
- an assembly tip in fluid communication with the addressable assay unit and comprising an opening, wherein the assembly tip is configured to place the addressable assay unit in fluid communication with the first reagent unit or the sample vessel of the cartridge;
- and
- a reader assembly configured to receive the cartridge and the assay assembly, wherein the reader assembly comprises:
- an automated fluid transfer device configured to move the assay assembly relative to the cartridge to selectively place the assembly tip of the assay assembly into the sample vessel or into the first reagent unit of the plurality of reagent units and to sequentially transfer the biological sample and the first cartridge reagent into the addressable assay unit via the assembly tip such that a reaction occurs that yields a signal indicative of a presence of the analyte, and
- a detection assembly configured to detect the signal indicative of the presence of the analyte.
9 more elements
Dependencies are inferred from the claim text.