Controllable sample introduction
AssigneeWaters Technologies Corporation
InventorsMichael R. Jackson, Joshua A. Burnett
Life of this patent
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Abstract
A method for injecting a sample into a flow of a liquid chromatography system includes providing a flow of a mobile phase, and injecting a volume of a sample into the flow of the mobile phase such that the concentration of the sample within the mobile phase varies with a triangular profile over the course of the injecting.
Claims20
A method for injecting a sample into a flow of a liquid chromatography system comprising:
- providing a flow of a mobile phase;
- and
- injecting a volume of a sample into the flow of the mobile phase such that the concentration of the sample within the mobile phase varies with a triangular profile over the course of the injecting, wherein the injecting the volume of the sample into the flow of the mobile phase includes increasing the flow of the sample until a peak is reached, and then immediately decreasing the flow of the sample to create a triangular velocity profile of the sample.
A liquid chromatography system comprising:
- a solvent delivery system configured to provide a flow of a mobile phase;
- a sample delivery system configured to inject a volume of a sample into the mobile phase;
- a control module in communication with at least one of the solvent delivery system and the sample delivery system, the control module configured to control a volumetric flow rate of the sample dispensed by the sample delivery system, the control module being configured to control concentration of the sample within the mobile phase such that the concentration of the sample within the mobile phase varies with a triangular profile over the course of injecting of the sample into the mobile phase by the sample delivery system, wherein the control module is configured to inject the volume of the sample into the flow of the mobile phase by increasing the flow of the sample until a peak is reached, and then immediately decreasing the flow of the sample to create a triangular velocity profile of the sample;
- a liquid chromatography column located downstream from the sample delivery system and the solvent delivery system;
- and
- a detector located downstream from the liquid chromatography column.
A computer program product, comprising one or more computer readable hardware storage devices storing a computer readable program code, the computer readable program code comprising an algorithm that when executed by one or more processors of a computing system of a liquid chromatography system, implements a method for injecting a sample into a flow of the liquid chromatography system, the method comprising:
- providing a flow of a mobile phase;
- and
- injecting a volume of a sample into the flow of the mobile phase such that the concentration of the sample within the mobile phase varies with a triangular velocity profile over the course of the injecting, wherein the injecting the volume of the sample into the flow of the mobile phase includes increasing the flow of the sample until a peak is reached, and then immediately decreasing the flow of the sample to create the triangular velocity profile of the sample.
Dependencies are inferred from the claim text.