A PET and Compton imaging method implemented by a device including at least two facing PET modules, wherein it comprises at least one Compton camera arranged outside a plane containing said PET modules for forming a trihedron with said PET modules and producing at least one Compton view, the acquisition fields of said PET and Compton views having at least one overlap area covering the object to be imaged, the method comprising:
- acquisitions according to three distinct Compton views;
- location of a dense area and its three-dimensional contour on said Compton views;
- computation of a 3D map of the probability of detection of the presence of a source from said Compton views;
- coincidence detection by the PET cameras and association of a response line (LOR);
- and
- segmentation of LORs crossing the dense area by using the detection probability determined by said Compton views.