Multivalent HIV vaccine boost compositions and methods of use
AssigneeGeoVax, Inc.
InventorHarriet Robinson
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Abstract
Compositions and methods of use are provided to boost a primed immune response to HIV. More specifically, the present invention relates to vaccine compositions comprising an HIV-protein boost or an MVA-expressed Env protein and methods of use. Exemplary HIV proteins for protein boosts include proteins such as gp120 proteins B.63521Δ11mutC and full-length single chain (FLSC), which has been modified to stabilize a CD4-induced Env structure. Exemplary MVAs expressing secreted Methods of administration and dosing regimens are also provided.
Claims14
A method for inducing an immune response to a human immunodeficiency virus (HIV) comprising administering to a human in need thereof:
- i) a prime vaccination comprising an effective amount of a DNA vector encoding Gag-Pol and Env and one or more of Tat, Rev, Nef, Vif, Vpr, or Vpu HIV-1 antigens that, when expressed, are displayed on virus-like particles (VLPs);
- and
- ii) a boost vaccination comprising
- a) an effective amount of a first modified vaccinia Ankara (MVA) vector encoding a membrane-bound HIV-1 envelope (Env) protein that, when expressed, is displayed on VLPs, and,
- b) an effective amount of a second MVA vector encoding an HIV-1 gp-140 protein.
A method for boosting an immune response to a human immunodeficiency virus (HIV) comprising administering to a human in need thereof a boost vaccination comprising:
- a) an effective amount of a first modified vaccinia Ankara (MVA) vector encoding a membrane-bound HIV-1 envelope (Env) protein that, when expressed, is displayed on virus-like particles (VLPs), and,
- b) an effective amount of a second MVA vector encoding an HIV-1 gp-140 protein,
- wherein, prior to the administration of the boost vaccination, the human has previously been administered one or more prime vaccinations comprising a DNA vector encoding Gag-Pol and Env and one or more of Tat, Rev, Nef, Vif, Vpr, or Vpu HIV-1 antigens.
Dependencies are inferred from the claim text.