Sugar derivatives and uses thereof to prepare novel senolytic agents

A compound Formula (II):

• or pharmaceutically available salts, hydrate and solvates thereof, wherein:
• R1 is —NH2;
• R2 is —H or —F;
• R3 is —H, —F, —OH, —OC(O)R11 or —OC(O)OR12;
• R4 is —H, —F, —OH, —OC(O)R13 or —OC(O)OR14;
• alternatively, both R3 and R4 together with the atoms to which they are bonded form a 5 membered cyclic acetal which is substituted by R19 at the acetal carbon;
• alternatively, both R3 and R4 together with the atoms to which they are bonded form a 5 membered cyclic carbonate;
• R5 is —CH3, —CH2OH, —OC(O)R17 or —OC(O)OR18;
• R6 is —H or —F;
• R7 is —H or —F;
• R8 is —H or —F;
• R9-R18 are independently alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, cycloalkyl, substituted cycloalkyl, cycloalkenyl, substituted cycloalkenyl, cycloheteroalkyl, substituted cycloheteroalkyl, cycloheteroalkenyl, substituted cycloheteroalkenyl, heteroaryl or substituted heteroaryl;
• and
• R19 is alkyl, substituted alkyl, aryl, substituted aryl, cycloalkyl, substituted cycloalkyl, cycloheteroalkyl, substituted cycloheteroalkyl, heteroaryl or substituted heteroaryl.