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US 11,897,907 B2Granted
Method for preparing glufosinate or analogues thereof
AssigneeLier Chemical Co., Ltd.
InventorsMin Xu, Yongjiang Liu, Lei Zhou, Wei Zeng, Ke Cheng
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Abstract
The present invention relates to a method for preparing glufosinate or analogues thereof.
Claims21
A method for preparing a glufosinate of formula (I) or an analogue thereof,
- which method comprises:
- a) feeding a compound of formula (II) and a compound of formula (V) into a first reactor set, wherein after reaction, a product stream of the first reactor set is obtained,
- b) feeding the product stream of the first reactor set into a second reactor set, and reacting the product stream at a temperature in the range of from 50° C. to 200° C. to obtain a product stream of the second reactor set;
- and
- c) subjecting the product stream of the second reactor set to an acidic hydrolysis or a basic hydrolysis to obtain the glufosinate of formula (I) or an analogue thereof;
- wherein X represents —OR2 or —NR2R′,
- R1, R2 and R7 are each independently selected from a substituted or unsubstituted hydrocarbyl group;
- R′ is hydrogen or has the same definition as R2;
- Hal1 and Hal2 are each independently halogen;
- and
- PG is hydrogen or an amino protecting group;
- and
- wherein the feeding in the step a) and/or step b) is/are a continuous feeding.
10 more elements
Dependencies are inferred from the claim text.