Degradable polymers of a cyclic silyl ether and uses thereof
AssigneeMassachusetts Institute of Technology
InventorsJeremiah A. Johnson, Peyton Shieh, Wenxu Zhang
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Abstract
The present disclosure provides cyclic silyl ethers of the formula: and salts thereof. The cyclic silyl ethers may be useful as monomers for preparing polymers. Also described herein are polymers prepared by polymerizing a cyclic silyl ether and optionally one or more additional monomers. The polymers may be degradable (e.g., biodegradable). One or more O—Si bonds of the polymers may be the degradation sites. Also described herein are compositions and kits including the cyclic silyl ethers or polymers; methods of preparing the polymers; and methods of using the polymers, compositions, and kits.
Claims35
A polymer prepared by a method comprising polymerizing:
- one or more instances of a first monomer, or a salt thereof;
- and
- a second monomer, wherein the second monomer is a compound of Formula (B):
- or a salt thereof, wherein any two instances of the first monomer are the same as or different from each other, and the second monomer is the same as or different from any instance of the first monomer;
- in the presence of a metathesis catalyst;
- wherein:
- Y is O or C(RQ)2;
- each instance of e is independently hydrogen, halogen, or substituted or unsubstituted, C1-6 alkyl;
- each instance of RK is independently hydrogen, halogen, substituted or unsubstituted, C1-10 alkyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or —ORN;
- each instance of RN is independently hydrogen, substituted or unsubstituted acyl, substituted or unsubstituted, C1-10 alkyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or an oxygen protecting group;
- j is 1, 2, or 3;
- and
- k is 0, 1, 2, or 3.
Dependencies are inferred from the claim text.