# US 11,897,892 B2 · Substituted pyridotriazine compounds and uses thereof

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- Number: US 11,897,892 B2
- Document ID: US11897892B2
- Status: Granted
- Kind: B2
- Application number: 18/164,317
- Filed: 2023-02-03
- Published: 2023-08-17
- Granted: 2024-02-13
- Earliest claimed: 2021-01-19
- Assignees: Gilead Sciences, Inc.
- Applicants: Gilead Sciences, Inc.
- Inventors: Hang Chu; Ana Z. Gonzalez Buenrostro; Hongyan Guo; Xiaochun Han; Anna E. Hurtley; Lan Jiang; Jiayao Li; David W. Lin; Michael L. Mitchell; Devan Naduthambi; Gregg M. Schwarzwalder; Suzanne M. Szewczyk; Matthew J. Von Bargen; Qiaoyin Wu; Hong Yang; Jennifer R. Zhang
- Web page: https://patentgrep.com/patent/US11897892B2

## CPC

- C07D 471/18: Bridged systems
- C07D 487/18: Bridged systems
- A61P 31/18: for HIV
- C07D 487/22: in which the condensed system contains four or more hetero rings
- C07D 491/22: in which the condensed system contains four or more hetero rings
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present disclosure relates generally to certain tricyclic compounds, pharmaceutical compositions comprising said compounds, and methods of making said compounds and pharmaceutical compositions. The compounds of the disclosure are useful in treating or preventing human immunodeficiency virus (HIV) infection.

## Claims

### Claim 1

A compound selected from the group consisting of:
or a pharmaceutically acceptable salt thereof.

### Claim 2 (depends on 1)

The compound of claim 1, wherein the compound is:
or a pharmaceutically acceptable salt thereof.

### Claim 3 (depends on 1)

The compound of claim 1, wherein the compound is:

### Claim 4 (depends on 1)

The compound of claim 1, wherein the compound is:
or a pharmaceutically acceptable salt thereof.

### Claim 5 (depends on 1)

The compound of claim 1, wherein the compound is:

### Claim 6 (depends on 1)

The compound of claim 1, wherein the compound is:
or a pharmaceutically acceptable salt thereof.

### Claim 7 (depends on 1)

The compound of claim 1, wherein the compound is:

### Claim 8 (depends on 1)

The compound of claim 1, wherein the compound is:
or a pharmaceutically acceptable salt thereof.

### Claim 9 (depends on 1)

The compound of claim 1, wherein the compound is:

### Claim 10 (depends on 1)

The compound of claim 1, wherein the compound is:
or a pharmaceutically acceptable salt thereof.

### Claim 11 (depends on 1)

The compound of claim 1, wherein the compound is:

### Claim 12 (depends on 1)

The compound of claim 1, wherein the compound is:
or a pharmaceutically acceptable salt thereof.

### Claim 13 (depends on 1)

The compound of claim 1, wherein the compound is:

### Claim 14 (depends on 1)

The compound of claim 1 wherein the compound is:
or a pharmaceutically acceptable salt thereof.

### Claim 15 (depends on 1)

The compound of claim 1, wherein the compound is:

### Claim 16 (depends on 1)

The compound of claim 1, wherein the compound is:
or a pharmaceutically acceptable salt thereof.

### Claim 17 (depends on 1)

The compound of claim 1, wherein the compound is:

### Claim 18 (depends on 1)

A pharmaceutical composition comprising a therapeutically effective amount of a compound of claim 1, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.

### Claim 19 (depends on 18)

The pharmaceutical composition of claim 18, wherein the pharmaceutical composition comprises the compound:
or a pharmaceutically acceptable salt thereof.

### Claim 20 (depends on 18)

The pharmaceutical composition of claim 18, wherein the pharmaceutical composition comprises the compound:
or the pharmaceutically acceptable salt thereof.

### Claim 21 (depends on 18)

The pharmaceutical composition of claim 18, wherein the pharmaceutical composition comprises the compound:
or the pharmaceutically acceptable salt thereof.

### Claim 22 (depends on 18)

The pharmaceutical composition of claim 18, wherein the pharmaceutical composition comprises the compound:
or the pharmaceutically acceptable salt thereof.

### Claim 23 (depends on 18)

The pharmaceutical composition of claim 18, wherein the pharmaceutical composition comprises the compound:
or the pharmaceutically acceptable salt thereof.

### Claim 24 (depends on 18)

The pharmaceutical composition of claim 18, wherein the pharmaceutical composition comprises the compound:
or the pharmaceutically acceptable salt thereof.

### Claim 25 (depends on 18)

The pharmaceutical composition of claim 18, wherein the pharmaceutical composition comprises the compound:
or the pharmaceutically acceptable salt thereof.

### Claim 26 (depends on 18)

The pharmaceutical composition of claim 18, wherein the pharmaceutical composition comprises the compound:
or the pharmaceutically acceptable salt thereof.

### Claim 27 (depends on 1)

A method of treating an HIV infection in a human having or at risk of having the infection, comprising administering to the human a therapeutically effective amount of a compound of claim 1, or a pharmaceutically acceptable salt thereof.

### Claim 28 (depends on 27)

The method of claim 27, comprising administering to the human a therapeutically effective amount of the compound:
or a pharmaceutically acceptable salt thereof.

### Claim 29 (depends on 27)

The method of claim 27, comprising administering to the human a therapeutically effective amount of the compound:
or a pharmaceutically acceptable salt thereof.

### Claim 30 (depends on 27)

The method of claim 27, comprising administering to the human a therapeutically effective amount of the compound:
or a pharmaceutically acceptable salt thereof.

### Claim 31 (depends on 27)

The method of claim 27, comprising administering to the human a therapeutically effective amount of the compound:
or a pharmaceutically acceptable salt thereof.

### Claim 32 (depends on 27)

The method of claim 27, comprising administering to the human a therapeutically effective amount of the compound:
or a pharmaceutically acceptable salt thereof.

### Claim 33 (depends on 27)

The method of claim 27, comprising administering to the human a therapeutically effective amount of the compound:
or a pharmaceutically acceptable salt thereof.

### Claim 34 (depends on 27)

The method of claim 27, comprising administering to the human a therapeutically effective amount of the compound:
or a pharmaceutically acceptable salt thereof.

### Claim 35 (depends on 27)

The method of claim 27, comprising administering to the human a therapeutically effective amount of the compound:
or a pharmaceutically acceptable salt thereof.